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MCT1 genetic polymorphism role during a circuit weight session in men and women
Research Areas
  • Physical education and sport
Recently it has been reported that men carrying the MCT1 A1470T polymorphism (rs1049434) showed a higher capillary lactate accumulation slope than non-carriers during circuit weight training (CWT) 2. The aim of the present work is to study whether the A1470T polymorphism effect is present also in women and if it is influenced by gender. Methods 15 men (mean±standard deviation; 22,53±2,59 yrs; 76,66±6,45 kg; 177,21±3,77 cm) and 14 women (20,14±2,77 yrs; 60,38±5,43 kg; 164,46±5,06 cm) performed a CWT of 8 machine exercises at 70% of 15RM. Venous blood lactate during the session was analyzed using the YSI 1500 SPORT Lactate Analyzer. The MCT1 A1470T polymorphism was determined by direct sequencing. Two ways ANOVA with repeated measures was used to determine differences between genetic groups in each gender. The significant level was set at alfa?0.05. Results Interaction between genetic group and measurement was found in men (p=0.004) but not in women (p=0.361). Bonferroni post hoc showed higher venous lactate values for AA compared to TT in men (p=0.008). Discussion Our results show different blood lactate accumulation depending on the A1470T polymorphism in men, confirming the influence of this genetic variant on lactate metabolism reported previously 2. However, with the same circuit we did not find effects of the polymorphism in the lactate curves in women, maybe because of their lower lactate concentrations when compared with men. If, as presumed, the lactate transporter MCT1 has a lactate threshold, the polymorphic MCT1 could have different effects in men than women. Moreover, when compared with previous studies, the polymorphism has different effect in capillary (arterialized blood) than in venous lactate levels2. These differences could be explained because a bidirectional function of MCT1 3. In conclusion, our results confirm an influence of A1470T polymorphism on lactate metabolism in men, but not in women, and a potential different effect in the arterial and venous lactate levels. However, further research is required to better define the MCT1 function and the polymorphism role during high intensity exercises. References 1. Juel, C. Eur J Appl Physiol (2001); 86: 12-6. 2. Cupeiro, R, et al. J Sci Med Sport (2010); 13: 526-30. 3. Manning Fox, JE, et al. J Physiol (2000); 529 Pt 2: 285-93.
16th Annual Congress of the European College os Sport Science
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Book of abstracts
  • Autor: Pedro Jose Benito Peinado (UPM)
  • Autor: Esther Morencos Martínez (UPM)
  • Autor: Fco. Javier Calderon Montero (UPM)
  • Autor: Ana Belen Peinado Lozano (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Ejercicio Físico, Salud y sus Fundamentos Fisiológicos (EFISAF)
  • Departamento: Salud y Rendimiento Humano
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)