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Applicability of the GP Device to the Circle of Willis Arteries by Using a Mathematical Model
Research Areas
  • Natural sciences and health sciences,
  • Mechanical aeronautics and naval engineering,
  • Information technology and adata processing
According to the World Health Organization [1] , 15 million people suffer stroke worldwide each year; of these, 5 million die and 5 million are permanently disabled. Stroke is therefore a major cause of mortality world-wide. The majority of strokes are caused by a blood clot that occludes an artery in the brain, and although thrombolytic agents such as Alteplase are used to dissolve clots that arise in the arteries of the brain, there are limitations on the use of these thrombolytic agents. However over the past decade, other methods of treatment have been developed which include Thrombectomy Devices e.g. the ?GP? Thrombus Aspiration Device (?GP? TAD). Such devices may be used as an alternative to thrombolytics or in conjunction with them to extract blood clots in arteries such as the middle cerebral artery of the midbrain brain, and the posterior inferior cerebellar artery (PICA) of the posterior aspect of the brain. In this paper, we mathematically model the removal of blood clots using the ?GP? TAD from selected arteries of the brain where blood clots may arise taking into account factors such as the resistances, compliances and inertances effects. Such mathematical modelling may have potential uses in predicting the pressures necessary to extract blood clots of given lengths, and masses from arteries in the Circle of Willis - posterior circulation of the brain.
13th International Conference on Modelling and Simulation - UkSim-AMSS 2011, de IEEE.
Cambridge, United Kingdom
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13th International Conference on Modelling and Simulation - UkSim-AMSS 2011, de IEEE
  • Autor: Gregorio Romero Rey (UPM)
  • Autor: Maria Luisa Martinez Muneta (UPM)
  • Autor: Luis Jesus Felez Mindan (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnologías ferroviarias y simulación avanzada
  • Departamento: Ingeniería Mecánica y de Fabricación
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)