Observatorio de I+D+i UPM

Memorias de investigación
Research Project:
MERIT: Metabolic Reprogramming by Induction of Transcription
Year:2011
Research Areas
Information
Abstract

Plants continually monitor the environment to modify physiology and development at the molecular level to ensure maximal fitness. Central in the signaling network is the SnRK1 kinases (homologous to AMPK and SNF1 in mammals and yeast respectively). These kinases are vital to the energy balance of the organism and regulate primary metabolism by controlling transcription factors, which control the expression of genes encoding key enzymes. SnRK1 signaling and reprogrammed metabolism have turned out to be crucial for establishments of tolerance and sustained growth during stress. This proposal suggests a multilevel approach to signaling in which all levels of the signal transduction pathway are addressed. The proposal is truly interdisciplinary and a wide range of methodology will be deployed ranging from classical physiology to state-of-the-art mass spectrometry based protein and metabolite profiling, massive sequencing of immuno-precipitated chromatin and whole genome expression profiling. This will be further supported by bioinformatic approaches, phylogenetical as well as network based.

The aim is to understand the mechanisms regulating energy balance in plants and their impact on plant performance under stress. Improved stress tolerance of plants is of strategic importance in a world with rising population and changing climate. This strategic importance as well as future recruitment possibilities motivates the high involvement of industrial partners in the proposed activities. The proposed training activities will coach future top-performers for professional career in the biotech industry as well as in the academia. The training program includes network-wide workshops (methodology, industry relevant skills and more) as well as structured local training in the host institutions. Important is a rich schedule of secondments in witch the young researchers will learn new technologies, widen their scientific horizons and establish their academic networks.

International
Si
Project type
Proyectos y convenios en convocatorias públicas competitivas
Company
Comisión Europea
Entity Nationality
BELGICA
Entity size
Grande
Granting date
19/11/2010
Participants
  • Participante: Anna Tatkiewicz (UPM)
  • Participante: Desiree Caudullo . (UPM)
  • Director: Jesus Vicente Carbajosa (UPM)
Research Group, Departaments and Institutes related
  • Creador: No seleccionado
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Grupo de Investigación: Redes Reguladoras del Desarrollo y Respuesta a Estrés en Plantas
  • Departamento: Biotecnología
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)