Research Publications in journals:
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
Molecular, cellular and genetic biology
The study of cross-reactivity in allergy is key to both understanding. the
allergic response of many patients and providing them with a rational treatment
In the present study, protein microarrays and a co-sensitization graph approach
were used in conjunction with an allergen microarray immunoassay. This enabled us
to include a wide number of proteins and a large number of patients, and to study
sensitization profiles among members of the LTP family. Fourteen LTPs from the
most frequent plant food-induced allergies in the geographical area studied were
printed into a microarray specifically designed for this research. 212 patients
with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited
from seven regions of Spain with different pollen profiles, and their sera were
tested with allergen microarray. This approach has proven itself to be a good
tool to study cross-reactivity between members of LTP family, and could become a
useful strategy to analyze other families of allergens.