Memorias de investigación
Artículos en revistas:
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
Año:2012
Áreas de investigación
  • Biología molecular, celular y genética
Datos
Descripción
The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
Internacional
Si
JCR del ISI
Si
Título de la revista
Plos One
ISSN
1932-6203
Factor de impacto JCR
4,092
Información de impacto
Volumen
7
DOI
10.1371/journal.pone.0050799
Número de revista
12
Desde la página
1
Hasta la página
10
Mes
DICIEMBRE
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Aranzazu Palacín Gómez UPM
  • Autor: Cristina Gomez Casado UPM
  • Autor: Luis A Rivas INTA-CSIC
  • Autor: Jacobo Aguirre Instituto de Investigacio¿n Sanitaria Princesa
  • Autor: Leticia Tordesillas Villuendas UPM
  • Autor: Joan Bartra CIBERES
  • Autor: Carlos Blanco Instituto de Investigacio¿n Sanitaria Princesa
  • Autor: Teresa Carrillo Hospital Universitario de Gran Canaria Dr. Negrin,
  • Autor: Javier Cuesta Herranz Fundacion Jimenez Diaz,
  • Autor: Consolación de Frutos Instituto de Investigacio¿n Sanitaria Princesa
  • Autor: Genoveva Garc¿a Allvarez-Eire Complexo Hospitalario, Ourense
  • Autor: Francisco J Fernandez General University Hospital, Miguel Hernandez University
  • Autor: Pedro Gamboa Hospital de Basurto
  • Autor: Rosa Muñoz CIBERES
  • Autor: Maria Rosa Sanchez-Monge Y Laguna de Rins UPM
  • Autor: Sofia Sirvent Universidad Complutense
  • Autor: Maria J Torres Fundacio¿n IMABIS-Carlos Haya Hospital
  • Autor: Susana Varela-Losada Complexo Hospitalario, Ourense
  • Autor: Rosalia Rodriguez Universidad Complutense
  • Autor: Victor Parro INTA-CSIC
  • Autor: Miguel Blanca Fundacio¿n IMABIS-Carlos Haya Hospital
  • Autor: Gabriel Salcedo UPM
  • Autor: Araceli Diaz Perales UPM
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Biotecnología de Proteínas Vegetales
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Departamento: Biotecnología