Memorias de investigación
Artículos en revistas:
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
Año:2012
Áreas de investigación
  • Biomedicina,
  • Biología molecular, celular y genética
Datos
Descripción
Temporal lobe epilepsy is a common, chronic neurological disorder characterized by recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that regulate post-transcriptional expression of protein-coding mRNAs, which may have key roles in the pathogenesis of neurological disorders. In experimental models of prolonged, injurious seizures (status epilepticus) and in human epilepsy, we found upregulation of miR-134, a brain-specific, activity-regulated miRNA that has been implicated in the control of dendritic spine morphology. Silencing of miR-134 expression in vivo using antagomirs reduced hippocampal CA3 pyramidal neuron dendrite spine density by 21% and rendered mice refractory to seizures and hippocampal injury caused by status epilepticus. Depletion of miR-134 after status epilepticus in mice reduced the later occurrence of spontaneous seizures by over 90% and mitigated the attendant pathological features of temporal lobe epilepsy. Thus, silencing miR-134 exerts prolonged seizure-suppressant and neuroprotective actions; determining whether these are anticonvulsant effects or are truly antiepileptogenic effects requires additional experimentation.
Internacional
Si
JCR del ISI
Si
Título de la revista
Nature
ISSN
0028-0836
Factor de impacto JCR
36,28
Información de impacto
Volumen
18
DOI
doi: 10.1038/nm.2834
Número de revista
7
Desde la página
1087
Hasta la página
1094
Mes
JULIO
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Participantes
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB