Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Three-Dimensional Analysis of Spiny Dendrites Using Straightening and Unrolling Transforms
Year:2012
Research Areas
  • Biomedicine
Information
Abstract
Current understanding of the synaptic organization of the brain depends to a large extent on knowledge about the synaptic inputs to the neurons. Indeed, the dendritic surfaces of pyramidal cells (the most common neuron in the cerebral cortex) are covered by thin protrusions named dendritic spines. These represent the targets of most excitatory synapses in the cerebral cortex and therefore, dendritic spines prove critical in learning, memory and cognition. This paper presents a new method that facilitates the analysis of the 3D structure of spine insertions in dendrites, providing insight on spine distribution patterns. This method is based both on the implementation of straightening and unrolling transformations to move the analysis process to a planar, unfolded arrangement, and on the design of DISPINE, an interactive environment that supports the visual analysis of 3D patterns.
International
Si
JCR
Si
Title
Neuroinformatics
ISBN
1539-2791
Impact factor JCR
2,973
Impact info
Volume
10
Journal number
4
From page
391
To page
407
Month
OCTUBRE
Ranking
Participants
  • Autor: Ruth Benavides Piccione (UPM)
  • Autor: Javier De Felipe Oroquieta (UPM)
Research Group, Departaments and Institutes related
  • Creador: Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)