Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Cognitive reserve is associated with the functional organization of brain networks in healthy aging: A MEG Study
Research Areas
  • Natural sciences and health sciences
The proportion of elderly people in the population has increased rapidly in the last century and consequently "healthy aging" is expected to become a critical area of research in neuroscience. Evidence reveals how healthy aging depends on three main behavioral factors: social lifestyle, cognitive activity and physical activity. In this study, we focused on the role of cognitive activity, concentrating specifically on educational and occupational attainment factors, which were considered two of the main pillars of cognitive reserve. 21 subjects with similar rates of social lifestyle, physical and cognitive activity were selected from a sample of 55 healthy adults. These subjects were divided into two groups according to their level of cognitive reserve; one group comprised subjects with high cognitive reserve (9 members) and the other contained those with low cognitive reserve (12 members). To evaluate the cortical brain connectivity network, all participants were recorded by Magnetoencephalography (MEG) while they performed a memory task (modified version of the Sternberg¿s Task). We then applied two algorithms (Phase Locking Value & Phase-Lag Index) to study the dynamics of functional connectivity. In response to the same task, the subjects with lower cognitive reserve presented higher functional connectivity than those with higher cognitive reserve. These results may indicate that participants with low cognitive reserve needed a greater 'effort' than those with high cognitive reserve to achieve the same level of cognitive performance. Therefore, we conclude that cognitive reserve contributes to the modulation of the functional connectivity patterns of the aging brain.
Frontiers in Aging Neuroscience
Impact factor JCR
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  • Autor: María Eugenia López García (UPM)
  • Autor: Sara Aurtentxe (Laboratorio Neurociencia Cognitiva, CTB)
  • Autor: Ricardo Bruña Fernandez (UPM)
  • Autor: Julia Guiomar Niso Galan (UPM)
  • Autor: Fernando Maestu Unturbe (UPM)
  • Autor: Ricardo Bajo Breton (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Tecnología Fotónica y Bioingeniería
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)