Memorias de investigación
Artículos en revistas:
Artificial Pancreas Using a Personalized Rule-Based Controller Achieves Overnight Normoglycemia in Patients with Type 1 Diabetes
Año:2013
Áreas de investigación
  • Biomedicina,
  • Tecnología electrónica y de las comunicaciones
Datos
Descripción
Objective: This study assessed the efficacy of a closed-loop (CL) system consisting of a predictive rule-based algorithm (pRBA) on achieving nocturnal and postprandial normoglycemia in patients with type 1 diabetes mellitus (T1DM). The algorithm is personalized for each patient?s data using two different strategies to control nocturnal and postprandial periods. Research Design and Methods: We performed a randomized crossover clinical study in which 10 T1DM patients treated with continuous subcutaneous insulin infusion (CSII) spent two nonconsecutive nights in the research facility: one with their usual CSII pattern (open-loop [OL]) and one controlled by the pRBA (CL). The CL period lasted from 10 p.m. to 10 a.m., including overnight control, and control of breakfast. Venous samples for blood glucose (BG) measurement were collected every 20 min. Results: Time spent in normoglycemia (BG, 3.9?8.0 mmol/L) during the nocturnal period (12 a.m.?8 a.m.), expressed as median (interquartile range), increased from 66.6% (8.3?75%) with OL to 95.8% (73?100%) using the CL algorithm (P < 0.05). Median time in hypoglycemia (BG, <3.9 mmol/L) was reduced from 4.2% (0?21%) in the OL night to 0.0% (0.0?0.0%) in the CL night (P < 0.05). Nine hypoglycemic events ( <3.9 mmol/L) were recorded with OL compared with one using CL. The postprandial glycemic excursion was not lower when the CL system was used in comparison with conventional preprandial bolus: time in target (3.9?10.0 mmol/L) 58.3% (29.1?87.5%) versus 50.0% (50?100%). Conclusions: A highly precise personalized pRBA obtains nocturnal normoglycemia, without significant hypoglycemia, in T1DM patients. There appears to be no clear benefit of CL over prandial bolus on the postprandial glycemia.
Internacional
Si
JCR del ISI
Si
Título de la revista
Diabetes Technology & Therapeutics
ISSN
1520-9156
Factor de impacto JCR
2,205
Información de impacto
Volumen
DOI
Número de revista
Desde la página
ONLINE
Hasta la página
ONLINE
Mes
OCTUBRE
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB