Descripción
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We present a biomolecular probabilistic model driven by the action of a DNA toolbox made of a set of DNA templates and enzymes that is able to perform Bayesian inference. The model will take single-stranded DNA as input data, representing the presence or absence of a specific molecular signal (the evidence). The program logic uses different DNA templates and their relative concentration ratios to encode the prior probability of a disease and the conditional probability of a signal given the disease. When the input and program molecules interact, an enzyme-driven cascade of reactions (DNA polymerase extension, nicking and degradation) is triggered, producing a different pair of single-stranded DNA species. Once the system reaches equilibrium, the ratio between the output species will represent the application of Bayes? law: the conditional probability of the disease given the signal. In other words, a qualitative diagnosis plus a quantitative degree of belief in that diagno- sis. Thanks to the inherent amplification capability of this DNA toolbox, the resulting system will be able to to scale up (with longer cascades and thus more input signals) a Bayesian biosensor that we designed previously. | |
Internacional
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Si |
Nombre congreso
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19th International Conference on DNA Computing and Molecular Programming |
Tipo de participación
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960 |
Lugar del congreso
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Arizona State University, Tempe. USA. |
Revisores
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Si |
ISBN o ISSN
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978-3-319-01928-4 |
DOI
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Fecha inicio congreso
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22/09/2013 |
Fecha fin congreso
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27/09/2013 |
Desde la página
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160 |
Hasta la página
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173 |
Título de las actas
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DNA Computing and molecular programming |