Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
White matter damage disorganizes brain functional networks in amnestic Mild Cognitive Impairment.
Año:2014
Áreas de investigación
  • Procesamiento de imágenes
Datos
Descripción
Although progressive functional brain network disruption has been one of the hallmarks of Alzheimer?s Dis- ease, little is known about the origin of this functional impairment that underlies cognitive symptoms. We in- vestigated how the loss of white matter (WM) integrity disrupts the organization of the functional networks at different frequency bands. The analyses were performed in a sample of healthy elders and mild cognitive im- pairment (MCI) subjects. Spontaneous brain magnetic activity (measured with magnetoencephalography) was characterized with phase synchronization analysis, and graph theory was applied to the functional networks. We identified WM areas (using diffusion weighted magnetic resonance imaging) that showed a statistical de- pendence between the fractional anisotropy and the graph metrics. These regions are part of an episodic mem- ory network and were also related to cognitive functions. Our data support the hypothesis that disruption of the anatomical networks influences the organization at the functional level resulting in the prodromal dementia syndrome of MCI.
Internacional
Si
JCR del ISI
Si
Título de la revista
Brain Connectivity
ISSN
2158-0014
Factor de impacto JCR
Información de impacto
Volumen
4
DOI
10.1016/j.neuroimage.2014.08.002
Número de revista
5
Desde la página
312
Hasta la página
322
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Jose Angel Pineda Pardo (UPM)
  • Autor: Mª Pilar Garcés López (UPM)
  • Autor: María Eugenia López (Universidad Complutense de Madrid)
  • Autor: Sara Aurtenetxe (Universidad Complutense de Madrid)
  • Autor: Pablo Cuesta (Universidad Complutense de Madrid)
  • Autor: Alberto Marcos (Hospital Clínico San Carlos)
  • Autor: Pedro Montejo (Auntamiento de Madrid)
  • Autor: Miguel Yus (Hospital Clínico San Carlos)
  • Autor: Juan Antonio Hernández Tamames (UPM)
  • Autor: Francisco del Pozo Guerrero (UPM)
  • Autor: James Becker (University of Pennsylvania)
  • Autor: Fernando Maestu Unturbe (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2018 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)