Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
White matter damage disorganizes brain functional networks in amnestic Mild Cognitive Impairment.
Year:2014
Research Areas
  • Image processing
Information
Abstract
Although progressive functional brain network disruption has been one of the hallmarks of Alzheimer?s Dis- ease, little is known about the origin of this functional impairment that underlies cognitive symptoms. We in- vestigated how the loss of white matter (WM) integrity disrupts the organization of the functional networks at different frequency bands. The analyses were performed in a sample of healthy elders and mild cognitive im- pairment (MCI) subjects. Spontaneous brain magnetic activity (measured with magnetoencephalography) was characterized with phase synchronization analysis, and graph theory was applied to the functional networks. We identified WM areas (using diffusion weighted magnetic resonance imaging) that showed a statistical de- pendence between the fractional anisotropy and the graph metrics. These regions are part of an episodic mem- ory network and were also related to cognitive functions. Our data support the hypothesis that disruption of the anatomical networks influences the organization at the functional level resulting in the prodromal dementia syndrome of MCI.
International
Si
JCR
Si
Title
Brain Connectivity
ISBN
2158-0014
Impact factor JCR
Impact info
Volume
4
10.1016/j.neuroimage.2014.08.002
Journal number
5
From page
312
To page
322
Month
SIN MES
Ranking
Participants
  • Autor: Jose Angel Pineda Pardo (UPM)
  • Autor: Mª Pilar Garcés López (UPM)
  • Autor: María Eugenia López (Universidad Complutense de Madrid)
  • Autor: Sara Aurtenetxe (Universidad Complutense de Madrid)
  • Autor: Pablo Cuesta (Universidad Complutense de Madrid)
  • Autor: Alberto Marcos (Hospital Clínico San Carlos)
  • Autor: Pedro Montejo (Auntamiento de Madrid)
  • Autor: Miguel Yus (Hospital Clínico San Carlos)
  • Autor: Juan Antonio Hernández Tamames (UPM)
  • Autor: Francisco del Pozo Guerrero (UPM)
  • Autor: James Becker (University of Pennsylvania)
  • Autor: Fernando Maestu Unturbe (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)