Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
The Default Mode Network is functionally and structurally disrupted in amnestic Mild Cognitive Impairment - a bimodal MEG-DTI study
Year:2014
Research Areas
  • Image processing
Information
Abstract
Over the past years, several studies on Mild Cognitive Impairment (MCI) and Alzheimer3s disease (AD) have re- ported Default Mode Network (DMN) deficits. This network is attracting increasing interest in the AD communi- ty, as it seems to play an important role in cognitive functioning and in beta amyloid deposition. Attention has been particularly drawn to how different DMN regions are connected using functional or structural connectivity. To this end, most studies have used functional Magnetic Resonance Imaging (fMRI), Positron Emission Tomogra- phy (PET) or Diffusion Tensor Imaging (DTI). In this study we evaluated (1) functional connectivity from resting state magnetoencephalography (MEG) and (2) structural connectivity from DTI in 26 MCI patients and 31 age- matched controls. Compared to controls, the DMN in the MCI group was functionally disrupted in the alpha band, while no differences were found for delta, theta, beta and gamma frequency bands. In addition, structural disconnection could be assessed through a decreased fractional anisotropy along tracts connecting different DMN regions. This suggests that the DMN functional and anatomical disconnection could represent a core feature of MCI.
International
Si
JCR
Si
Title
Neuroimage Clinical
ISBN
2213-1582
Impact factor JCR
Impact info
Volume
6
10.1016/j.nicl.2014.09.004
Journal number
From page
214
To page
221
Month
SIN MES
Ranking
Participants
  • Autor: Mª Pilar Garcés López (UPM)
  • Autor: Jose Angel Pineda Pardo (UPM)
  • Autor: Leonides Canuet Delis (UPM)
  • Autor: Sara Aurtenetxe (Universidad Complutense de Madrid)
  • Autor: María Eugenia López (Universidad Complutense de Madrid)
  • Autor: Alberto Marcos (Hospital Clínico San Carlos)
  • Autor: Miguel Yus (Hospital Clínico San Carlos)
  • Autor: Marcos Llanero-Luque
  • Autor: Francisco del Pozo Guerrero (UPM)
  • Autor: Miguel Sancho (Universidad Complutense de Madrid)
  • Autor: Fernando Maestu Unturbe (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)