Memorias de investigación
Artículos en revistas:
The Default Mode Network is functionally and structurally disrupted in amnestic Mild Cognitive Impairment - a bimodal MEG-DTI study
Año:2014
Áreas de investigación
  • Procesamiento de imágenes
Datos
Descripción
Over the past years, several studies on Mild Cognitive Impairment (MCI) and Alzheimer3s disease (AD) have re- ported Default Mode Network (DMN) deficits. This network is attracting increasing interest in the AD communi- ty, as it seems to play an important role in cognitive functioning and in beta amyloid deposition. Attention has been particularly drawn to how different DMN regions are connected using functional or structural connectivity. To this end, most studies have used functional Magnetic Resonance Imaging (fMRI), Positron Emission Tomogra- phy (PET) or Diffusion Tensor Imaging (DTI). In this study we evaluated (1) functional connectivity from resting state magnetoencephalography (MEG) and (2) structural connectivity from DTI in 26 MCI patients and 31 age- matched controls. Compared to controls, the DMN in the MCI group was functionally disrupted in the alpha band, while no differences were found for delta, theta, beta and gamma frequency bands. In addition, structural disconnection could be assessed through a decreased fractional anisotropy along tracts connecting different DMN regions. This suggests that the DMN functional and anatomical disconnection could represent a core feature of MCI.
Internacional
Si
JCR del ISI
Si
Título de la revista
Neuroimage Clinical
ISSN
2213-1582
Factor de impacto JCR
Información de impacto
Volumen
6
DOI
10.1016/j.nicl.2014.09.004
Número de revista
Desde la página
214
Hasta la página
221
Mes
SIN MES
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Participantes
  • Autor: Mª Pilar Garcés López UPM
  • Autor: Jose Angel Pineda Pardo UPM
  • Autor: Leonides Canuet Delis UPM
  • Autor: Sara Aurtenetxe Universidad Complutense de Madrid
  • Autor: María Eugenia López Universidad Complutense de Madrid
  • Autor: Alberto Marcos Hospital Clínico San Carlos
  • Autor: Miguel Yus Hospital Clínico San Carlos
  • Autor: Marcos Llanero-Luque
  • Autor: Francisco del Pozo Guerrero UPM
  • Autor: Miguel Sancho Universidad Complutense de Madrid
  • Autor: Fernando Maestu Unturbe UPM
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería