Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Alpha band hypersynchronization in progressive mild cognitive impairment. A MEG study
Year:2014
Research Areas
  • Cognitive neuroscience
Information
Abstract
People with mild cognitive impairment (MCI) show a high risk to develop Alzheimer?s disease (AD; Petersen et al., 2001). Nonetheless, there is a lack of studies about how functional connectivity patterns may distinguish between progressive (pMCI) and stable (sMCI) MCI patients. To examine whether there were differences in functional connectivity between groups, MEG eyes-closed recordings from 30 sMCI and 19 pMCI subjects were compared. The average conversion time of pMCI was 1 year, so they were considered as fast converters. To this end, functional connectivity in different frequency bands was assessed with phase locking value in source space. Then the significant differences between both groups were correlated with neuropsychological scores and entorhinal, parahippocampal, and hippocampal volumes. Both groups did not differ in age, gender, or educational level. pMCI patients obtained lower scores in episodic and semantic memory and also in executive functioning. At the structural level, there were no differences in hippocampal volume, although some were found in left entorhinal volume between both groups. Additionally, pMCI patients exhibit a higher synchronization in the alpha band between the right anterior cingulate and temporo-occipital regions than sMCI subjects. This hypersynchronization was inversely correlated with cognitive performance, both hippocampal volumes, and left entorhinal volume. The increase in phase synchro- nization between the right anterior cingulate and temporo-occipital areas may be predictive of conversion from MCI to AD.
International
Si
JCR
Si
Title
Journal of Neuroscience
ISBN
0270-6474
Impact factor JCR
7,115
Impact info
Volume
34
Journal number
44
From page
14551
To page
14559
Month
SIN MES
Ranking
Participants
  • Autor: María Eugenia López (Universidad Complutense de Madrid)
  • Autor: Ricardo Bruña Fernandez (UPM)
  • Autor: Sara Aurtenetxe (Universidad Complutense de Madrid)
  • Autor: Jose Angel Pineda Pardo (UPM)
  • Autor: Alberto Marcos (Hospital Clínico San Carlos)
  • Autor: Juan Arrazola (Hospital Clínico San Carlos)
  • Autor: Ana Isabel Reinoso (Centro para prevención del deterioro cognitivo)
  • Autor: Pedro Montejo (Centro para prevención del deterioro cognitivo)
  • Autor: Ricardo Bajo Breton (UPM)
  • Autor: Fernando Maestu Unturbe (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Bioingeniería y Telemedicina
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)