Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Scopolamine effects on functional brain connectivity: a pharmacological model of Alzheimer's disease
Año:2015
Áreas de investigación
  • Biomedicina,
  • Bioinstrumentación
Datos
Descripción
Scopolamine administration may be considered as a psychopharmacological model of Alzheimer's disease (AD). Here, we studied a group of healthy elderly under scopolamine to test whether it elicits similar changes in brain connectivity as those observed in AD, thereby verifying a possible model of AD impairment. We did it by testing healthy elderly subjects in two experimental conditions: glycopyrrolate (placebo) and scopolamine administration. We then analyzed magnetoencephalographic (MEG) data corresponding to both conditions in resting-state with eyes closed. This analysis was performed in source space by combining a nonlinear frequency band-specific measure of functional connectivity (phase locking value, PLV) with network analysis methods. Under scopolamine, functional connectivity between several brain areas was significantly reduced as compared to placebo, in most frequency bands analyzed. Besides, regarding the two complex network indices studied (clustering and shortest path length), clustering significantly decreased in the alpha band while shortest path length significantly increased also in alpha band both after scopolamine administration. Overall our findings indicate that both PLV and graph analysis are suitable tools to measure brain connectivity changes induced by scopolamine, which causes alterations in brain connectivity apparently similar to those reported in AD.
Internacional
Si
JCR del ISI
Si
Título de la revista
Scientific Reports
ISSN
2045-2322
Factor de impacto JCR
2,927
Información de impacto
Datos JCR del año 2012
Volumen
accepted
DOI
Número de revista
Desde la página
1
Hasta la página
3
Mes
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Participantes
  • Autor: Ricardo Bajo Breton (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Departamento: Tecnología Fotónica y Bioingeniería
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