Descripción
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In vitro primary cultures of dissociated invertebrate neurons from locust ganglia are used to experimentally investigate the morphological evolution of assemblies of living neurons, as they self-organize from collections of separated cells into elaborated, clustered, networks. At all the different stages of the culture's development, identification of neurons' and neurites' location by means of a dedicated software allows to ultimately extract an adjacency matrix from each image of the culture. In turn, a systematic statistical analysis of a group of topological observables grants us the possibility of quantifying and tracking the progression of the main network's characteristics during the self-organization process of the culture. Our results point to the existence of a particular state corresponding to a small-world network configuration, in which several relevant graph's micro- and meso-scale properties emerge. Finally, we identify the main physical processes ruling the culture's morphological transformations, and embed them into a simplified growth model qualitatively reproducing the overall set of experimental observations. | |
Internacional
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Si |
JCR del ISI
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Si |
Título de la revista
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Plos One |
ISSN
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1932-6203 |
Factor de impacto JCR
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3,73 |
Información de impacto
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Datos JCR del año 2012 |
Volumen
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DOI
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Número de revista
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Desde la página
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1 |
Hasta la página
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8 |
Mes
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ENERO |
Ranking
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