Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Network disruption and cerebrospinal fluid amyloid-beta and phospho-tau levels in Mild Cognitive Impairment
Year:2015
Research Areas
  • Clinical medicine and epidemiology,
  • Biomedicine,
  • Cognitive proceedings,
  • Engineering
Information
Abstract
Synaptic dysfunction is a core deficit in Alzheimer's disease, preceding hallmark pathological abnormalities. We used resting-state magnetoencephalography to assess whether functional connectivity patterns, as an index of synaptic dysfunction, associate with cerebrospinal fluid (CSF) biomarkers (i.e., phospho-tau and amyloid beta -A?42- levels) in a sample of twelve patients with Mild Cognitive Impairment. We also evaluated the association between aberrant functional connections and structural connectivity abnormalities, measured with diffusion tensor imaging, as well as the convergent impact of cognitive deficits and CSF variables on network disorganization. One third of the patients converted to Alzheimer's disease during a follow-up period of 2.5 years. Patients with abnomal CSF phospho-tau and A?42 levels exhibited both reduced and increased functional connectivity affecting limbic structures such as the anterior/posterior cingulate cortex, orbitofrontal cortex, and medial temporal areas in different frequency bands. A reduction in posterior cingulate functional connectivity mediated by phospho-tau associated with impaired axonal integrity of the hippocampal cingulum. We noted that several connectivity abnormalities were predicted by CSF biomarkers and cognitive scores. These preliminary results indicate that CSF markers of amyloid deposition and neuronal injury in early Alzheimer's disease associate with a dual pattern of cortical network disruption, affecting key regions of the Default Mode Network and the temporal cortex. Magnetoencephalography is useful to detect early synaptic dysfunction associated with Alzheimer's disease brain pathology in terms of functional network organization.
International
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JCR
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Title
The Journal of Neuroscience
ISBN
0270-6474
Impact factor JCR
6,747
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Participants
  • Autor: Leonides Canuet Delis (UPM)
  • Autor: Sandra Pusil Arce (UPM)
  • Autor: Maria Eugenia Lopez Lambas (UPM)
  • Autor: Ricardo Bajo Breton (UPM)
  • Autor: Jose Angel Pineda Pardo (UPM)
  • Autor: Pablo Cuesta Prieto (UPM)
  • Autor: Gerardo Miguel Galvez Garcia (UPM)
  • Autor: Jose Maria Gaztelu (Hospital Ramon y Cajal)
  • Autor: Daniel Lourido (Hospital Ramon y Cajal)
  • Autor: Guillermo Garcia-Ribas (Hospital Ramon y Cajal)
  • Autor: Fernando Maestu Unturbe (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Tecnología Fotónica y Bioingeniería
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)