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Effects of vitamin C and E supplementation in hepcidin secretion and iron regulation
Áreas de investigación
  • Ciencias naturales y ciencias de la salud
Introduction The main regulator of iron metabolism is the hepatic antimicrobial peptide hepcidin. Hepcidin acts by inhibiting cellular iron efflux through binding to and inducing the degradation of ferroportin, the sole known cellular iron exporter (1). Exercise and muscle contraction increase hepcidin response, causing an iron absorption reduction (2). Therefore, this response was proposed to explain iron deficiency among athletes. Thus, the aim of this study is to elucidate the influence of vitamin C and E in the regulation of hepcidin after exercise in healthy humans. Methods Ten well-trained male students of Sport Sciences (26.9 ± 6.7 years, 69.3 ± 8.8kg and 176.6 ± 7.5cm) participated in this study. Subjects received an oral supplementation with a combination of ascorbic acid (500mg/day) and RRR-?- tocopherol (400 IU/day). Before and after 28 days of supplementation the participants performed 1.5 h running trial at the speed corresponding to the 75% of the maximum oxygen consumption (VO2max) previously determined. Venous blood samples were obtained pretrial (BS), immediately post-trial (0 h), and at 3, 6, and 10 h post-trial. Results There were not significant differences in hepcidin levels between before and after supplementation at the different measures times pre and post-trials (BS: 11.84±5.18 vs. 12.13±7.47 ng/mL; 0 h: 13.45±6.20 vs. 15.02±10.11 ng/mL; 3 h: 26.90±12.51 vs. 26.69±11.86 ng/mL; 6 h: 23.67±10.24 vs. 23.72±11.71 ng/mL; 10 h: 17.22±7.99 vs. 16.51±8.06 ng/mL, respectively). However, hepcidin response was significantly higher after exercise regarding to baseline levels. Discussion Hepcidin levels were greater after exercise regarding to baseline levels. These results are similar to those obtained by Peeling et al. (2). However, supplementation with vitamin C and E did not seem to influence hepcidin response. The peak of hepcidin was reached three hours post-trial as Kemna et al. reported in their study (3). Nevertheless, hepcidin values were maintained over baseline levels until 10 hours post-trial. Thus, these high levels could indicate us when the athletes? supplementation should start. References 1. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annual review of nutrition. 2006;26:323-42. 2. Peeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW, et al. Training surface and intensity: inflammation, hemolysis, and hepcidin expression. Medicine and Science in Sports and Exercise. 2009;41(1138-1145). 3. Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood. 2005;106(5):1864-6. Contact: laurabarbamoreno91@ gmail.com
Nombre congreso
19th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE
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Título de las actas
19th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE 2nd - 5th July 2014, Amsterdam ? The Netherlands BOOK OF ABSTRACTS
Esta actividad pertenece a memorias de investigación
  • Autor: Laura Barba
  • Autor: Ana Belen Peinado Lozano (UPM)
  • Autor: Javier Butragueño Revenga (UPM)
  • Autor: Víctor Díaz
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  • Creador: Grupo de Investigación: Ejercicio Físico, Salud y sus Fundamentos Fisiológicos (EFISAF)
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