Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Basophil response to peanut allergens in Mediterranean peanut-allergic patients
Year:2014
Research Areas
  • Biomedicine
Information
Abstract
Ara h 1, Ara h 2, and Ara h 3 are important sensitizers in peanut allergy. Ara h 9 has also been shown to be relevant in the Mediterranean area. We evaluated the basophil response to peanut allergens and Pru p 3 in Mediterranean patients: Group 1, peanut and peach allergy; Group 2, peanut allergy and tolerance to peach; Group 3, peach allergy and tolerance to peanut; Group 4, nonallergic subjects that tolerate both peanut and peach. Compared to controls (Group 4), there was an increased basophil activation with Ara h 2 (P = 0.031) and Pru p 3 (P = 0.009) in Group 1 and with Ara h 1 (P = 0.016), Ara h 2 (P = 0.001), and Ara h 9 (P = 0.016) in Group 2. Importantly, only Ara h 2 showed an increased activation (P = 0.009) in Group 2 compared to Group 3. Ara h 2 is the best discriminating allergen for peanut allergy diagnosis in a Mediterranean population showing two patterns: patients also allergic to peach, responding to Ara h 2 and Pru p 3, and patients allergic only to peanut, responding to Ara h 1, Ara h 2, and Ara h 9.
International
Si
JCR
Si
Title
Allergy
ISBN
0105-4538
Impact factor JCR
5,995
Impact info
Volume
Journal number
From page
964
To page
968
Month
JULIO
Ranking
Participants
  • Autor: C Mayorga
  • Autor: F Gomez
  • Autor: A Aranda
  • Autor: SJ Koppelman
  • Autor: Araceli Diaz Perales (UPM)
  • Autor: N Blanca López
  • Autor: AB Blázquez
  • Autor: M Blanca
  • Autor: MJ Torres
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Departamento: Biotecnología - Biología Vegetal
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)