Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Alt a 1 from Alternaria Alternata interacts with PR5 thaumatin-like proteins.
Year:2014
Research Areas
  • Biomedicine
Information
Abstract
Alt a 1 is a protein found in Alternaria alternata spores related to virulence and pathogenicity and considered to be responsible for chronic asthma in children. We found that spores of Alternaria inoculated on the outer surface of kiwifruits did not develop hyphae. Nevertheless, the expression of Alt a 1 gene was upregulated, and the protein was detected in the pulp where it co-localized with kiwi PR5. Pull-down assays demonstrated experimentally that the two proteins interact in such a way that Alt a 1 inhibits the enzymatic activity of PR5. These results are relevant not only for plant defense, but also for human health as patients with chronic asthma could suffer from an allergic reaction when they eat fruit contaminated with Alternaria.
International
Si
JCR
Si
Title
Febs Letters
ISBN
0014-5793
Impact factor JCR
3,341
Impact info
Volume
Journal number
From page
1501
To page
1508
Month
SIN MES
Ranking
Participants
  • Autor: Cristina Gomez Casado (UPM)
  • Autor: Maria Garrido Arandia (UPM)
  • Autor: Amaya Murua Garcia (UPM)
  • Autor: Pablo Gonzalez-Melendi De Leon (UPM)
  • Autor: Rosa Sánchez-Monge
  • Autor: Domingo Barber
  • Autor: Luis Fernandez Pacios (UPM)
  • Autor: Araceli Diaz Perales (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Interacciones moleculares planta-insecto.
  • Grupo de Investigación: Biotecnología Vegetal
  • Departamento: Sistemas y Recursos Naturales
  • Departamento: Biotecnología - Biología Vegetal
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)