Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Molecular Dynamics of Major Allergens from Alternaria, Birch Pollen and Peach
Year:2014
Research Areas
  • Molecular, cellular and genetic biology
Information
Abstract
Abstract: In the search for factors that make a protein allergenic (an issue that remains so far elusive) some common features of allergens such as small size, high stability and lipid binding are recognized in spite of their structural diversity. Other relevant but still poorly understood feature is their capability to form homodimers. We investigated by means of Molecular Dynamics (MD) calculations the stability in solution of several dimers of three major allergens from Alternaria mold, birch pollen, and peach fruit known to play essential roles in allergic disease. By running 20 ns MD simulations we found essential properties on solution that provide information of interest on their dimerization, stability of their epitopes and dynamical features of ligand binding cavities. Our results show that three essential allergen proteins display a distinct behavior on their trends to form homodimers in solution.
International
Si
JCR
Si
Title
Molecular Informatics
ISBN
1868-1743
Impact factor JCR
2,013
Impact info
Volume
Journal number
From page
682
To page
694
Month
SIN MES
Ranking
Participants
  • Autor: Maria Garrido Arandia (UPM)
  • Autor: Araceli Diaz Perales (UPM)
  • Autor: Luis Fernandez Pacios (UPM)
  • Autor: Cristina Gomez Casado (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Departamento: Sistemas y Recursos Naturales
  • Departamento: Biotecnología - Biología Vegetal
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)