Observatorio de I+D+i UPM

Memorias de investigación
Communications at congresses:
Interactive exploratory data analysis tool in Alzheimer's disease
Year:2015
Research Areas
  • Computational biology,
  • Information technology and adata processing
Information
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive impairment, and a variety of neuropathological changes, which are not homogenous between different brain regions within a given patient or between patients. The availability of techniques to explore the brain provides neuroscientists a wealth of data that is difficult to analyze, as a result of both its volume and its complexity. In order to overcome this problem, we propose to apply a new interactive exploratory data analysis tool, MorExAn (Morphology Exploratory Analyzer), which has been specifically designed to facilitate the study of complex neuroscientific data. In the present study, we used brain tissue from 10 patients with AD (age range 76 - 90 years old). We included quantitative stereological data of several histological features (e.g., neuron and plaques density) obtained from different hippocampal regions, as well as neuropsychological data and common clinical variables. Simultaneous analysis of data using MorExAn allows researchers to immediately detect possible differences between regions and relationships between different types of data. Thus, MorExAn provide us the possibility to relate histopathological data with neuropsychological and clinical variables. The aid of this interactive visualization tool brings us the possibility to find unexpected conclusions beyond the insight provided by simple statistics analysis, as well as to improve neuroscientists? productivity.
International
Si
Congress
Conference Abstract: B·DEBATE | A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing (Workshop)
960
Place
Barcelona, Spain
Reviewers
Si
ISBN/ISSN
1662-5137
10.3389/conf.fnsys.2015.06.00002
Start Date
29/04/2015
End Date
30/04/2015
From page
1
To page
1
A Dialogue with the Cerebral Cortex: Cortical Function and Interfacing
Participants
  • Autor: Yulia Diana Furcila . (UPM)
  • Autor: Juan Morales Del Olmo (UPM)
  • Autor: Angel Rodriguez Mtnez.de Bartolome (UPM)
  • Autor: Javier De Felipe Oroquieta (UPM)
  • Autor: Lidia Alonso Nanclares (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Minería de Datos y Simulación (MIDAS)
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Centro o Instituto I+D+i: Centro de Investigación en Simulación Computacional
  • Departamento: Arquitectura y Tecnología de Sistemas Informáticos
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)