Observatorio de I+D+i UPM

Memorias de investigación
Capítulo de libro:
Gating of thermally activated channels.
Año:2014
Áreas de investigación
  • Ciencias naturales y ciencias de la salud,
  • Biología estructural
Datos
Descripción
A class of ion channels that belongs to the transient receptor potential (TRP) superfamily and is present in specialized neurons that project to the skin has evolved as temperature detectors. These channels are classified into subfamilies, namely canonical (TRPC), melastatin (TRPM), ankyrin (TRPA), and vanilloid (TRPV). Some of these channels are activated by heat (TRPM2/4/5, TRPV1-4), while others by cold (TRPA1, TRPC5, and TRPM8). The general structure of these channels is closely related to that of the voltage-dependent K(+) channels, with their subunits containing six transmembrane segments that form tetramers. Thermal TRP channels are polymodal receptors. That is, they can be activated by temperature, voltage, pH, lipids, and agonists. The high temperature sensitivity in these thermal TRP channels is due to a large enthalpy change (?100 kcal/mol), which is about five times the enthalpy change in voltage-dependent gating. The characterization of the macroscopic currents and single-channel analysis demonstrated that gating by temperature is complex and best described by branched or allosteric models containing several closed and open states. The identification of molecular determinants of temperature sensitivity in TRPV1, TRPA1, and TRPV3 strongly suggest that thermal sensitivity arises from a specific protein domain.
Internacional
Si
DOI
10.1016/B978-0-12-800181-3.00003-8
Edición del Libro
1
Editorial del Libro
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
ISBN
978-0-12-800181-3
Serie
Current Topics in Membranes
Título del Libro
Thermal Sensors
Desde página
51
Hasta página
87
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: David Baez (Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile)
  • Autor: Natalia Raddatz . (UPM)
  • Autor: Gonzalo Ferreira (Laboratorio de Canales Iónicos, Departamento de Biofísica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay)
  • Autor: Carlos Gonzalez (Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile)
  • Autor: Ramón Latorre (Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Departamento: Biotecnología - Biología Vegetal
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