Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Parenclitic networks: uncovering new functions in biological data
Year:2014
Research Areas
  • Functional biology,
  • Computational biology
Information
Abstract
We introduce a novel method to represent time independent, scalar data sets as complex networks. We apply our method to investigate gene expression in the response to osmotic stress of Arabidopsis thaliana. In the proposed network representation, the most important genes for the plant response turn out to be the nodes with highest centrality in appropriately reconstructed networks. We also performed a target experiment, in which the predicted genes were artificially induced one by one, and the growth of the corresponding phenotypes compared to that of the wild-type. The joint application of the network reconstruction method and of the in vivo experiments allowed identifying 15 previously unknown key genes, and provided models of their mutual relationships. This novel representation extends the use of graph theory to data sets hitherto considered outside of the realm of its application, vastly simplifying the characterization of their underlying structure.
International
Si
JCR
Si
Title
Scientific Reports
ISBN
2045-2322
Impact factor JCR
5,578
Impact info
Datos JCR del año 2014
Volume
4
10.1038/srep05112
Journal number
5112
From page
1
To page
6
Month
MAYO
Ranking
Participants
  • Autor: Massimiliano Zanin Zanin (UPM)
  • Autor: Joaquin Medina Alcazar (UPM)
  • Autor: Jesus Vicente Carbajosa (UPM)
  • Autor: Dennys Marcela Gomez Paez (UPM)
  • Autor: David Papo . (UPM)
  • Autor: Pedro Sousa (Faculdade de Ciências e Tecnologia, Departamento de Engenharia Electrotécnica, Universidade Nova de Lisboa)
  • Autor: Ernestina Menasalvas Ruiz (UPM)
  • Autor: Stefano Boccaletti (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Lenguajes y Sistemas Informáticos e Ingeniería de Software
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)