Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues.
Year:2015
Research Areas
  • Natural sciences and health sciences
Information
Abstract
Life-long hematopoietic demands are met by a pool of hematopoietic stem cells (HSC) with self-renewal and multipotential differentiation ability. Humoral and paracrine signals from the bone marrow (BM) hematopoietic microenvironment control HSC activity. Cell-to-cell communication through connexin (Cx) containing gap junctions (GJs) allows pluricellular coordination and synchronization through transfer of small molecules with messenger activity. Hematopoietic and surrounding nonhematopoietic cells communicate each other through GJs, which regulate fetal and postnatal HSC content and function in hematopoietic tissues. Traffic of HSC between peripheral blood and BM is also dependent on Cx proteins. Cx mutations are associated with human disease and hematopoietic dysfunction and Cx signaling may represent a target for therapeutic intervention. In this review, we illustrate and highlight the importance of Cxs in the regulation of hematopoietic homeostasis under normal and pathological conditions
International
Si
JCR
Si
Title
International Review of Cell And Molecular Biology
ISBN
1937-6448
Impact factor JCR
4,522
Impact info
Volume
318
10.1016/bs.ircmb.2015.06.001
Journal number
From page
27
To page
62
Month
SIN MES
Ranking
Participants
  • Autor: Laura Fernández García (UPM)
  • Autor: Daniel Gonzalez Nieto (UPM)
  • Autor: KH Chang
  • Autor: I Fasciani
  • Autor: R Nayak
  • Autor: LC Barrio
  • Autor: JA Cancelas
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnologías para Ciencias de la Salud
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)