Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
Optical Hyperthermia Using Anti-Epidermal Growth Factor Receptor-Conjugated Gold Nanorods to Induce Cell Death in Glioblastoma Cell Lines
Año:2015
Áreas de investigación
  • Tecnología electrónica y de las comunicaciones
Datos
Descripción
Gold nanorods (GNRs) are able to efficiently convert absorbed light into localized heat within a short period of time due to the surface plasmon resonance effect. This property, along with their easy bioconjugation, allows the use of GNRs in photothermal therapy as selective photothermal agents to target cancer cells. In this study, GNRs were combined with an antibody against anti-epidermal growth factor receptor (EGFR), a receptor that is frequently overexpressed in brain tumors, and the potential of the nanoconjugate (EGFR-GNRs) to eliminate tumor cells was assessed in vitro. Two human glioblastoma cell lines (U373-MG and 1321N1) expressing EGFR at different levels were incubated with unfunctionalized GNRs and EGFR-GNRs, and then exposed to irradiation with a continuous-wave laser at 808 nm. The pretreatment with the EGFR-GNR nanoconjugate significantly increased the cell death rate after laser irradiation compared to unconjugated GNRs. No photothermal cell destruction was observed in the absence of GNRs. Our data suggest that the EGFR modification improves GNR-mediated cell death after laser irradiation, even when EGFR is present at low doses in cancer cells, and may have the potential to be used clinically as a tool to help complete resection of brain tumors during surgery.
Internacional
Si
JCR del ISI
Si
Título de la revista
Journal of Nanoscience And Nanotechnology
ISSN
1533-4880
Factor de impacto JCR
1,339
Información de impacto
Volumen
16
DOI
Número de revista
Desde la página
1
Hasta la página
7
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: Jose Javier Serrano Olmedo (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Tecnologías de Apoyo a la Vida
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2018 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)