Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Optical Hyperthermia Using Anti-Epidermal Growth Factor Receptor-Conjugated Gold Nanorods to Induce Cell Death in Glioblastoma Cell Lines
Year:2015
Research Areas
  • Electronic technology and of the communications
Information
Abstract
Gold nanorods (GNRs) are able to efficiently convert absorbed light into localized heat within a short period of time due to the surface plasmon resonance effect. This property, along with their easy bioconjugation, allows the use of GNRs in photothermal therapy as selective photothermal agents to target cancer cells. In this study, GNRs were combined with an antibody against anti-epidermal growth factor receptor (EGFR), a receptor that is frequently overexpressed in brain tumors, and the potential of the nanoconjugate (EGFR-GNRs) to eliminate tumor cells was assessed in vitro. Two human glioblastoma cell lines (U373-MG and 1321N1) expressing EGFR at different levels were incubated with unfunctionalized GNRs and EGFR-GNRs, and then exposed to irradiation with a continuous-wave laser at 808 nm. The pretreatment with the EGFR-GNR nanoconjugate significantly increased the cell death rate after laser irradiation compared to unconjugated GNRs. No photothermal cell destruction was observed in the absence of GNRs. Our data suggest that the EGFR modification improves GNR-mediated cell death after laser irradiation, even when EGFR is present at low doses in cancer cells, and may have the potential to be used clinically as a tool to help complete resection of brain tumors during surgery.
International
Si
JCR
Si
Title
Journal of Nanoscience And Nanotechnology
ISBN
1533-4880
Impact factor JCR
1,339
Impact info
Volume
16
Journal number
From page
1
To page
7
Month
SIN MES
Ranking
Participants
  • Autor: Jose Javier Serrano Olmedo (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnologías de Apoyo a la Vida
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)