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Descripción
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| In Magnetic Resonance Imaging (MRI), the use of Magnetic Nanoparticles (MNPs) as a Contrast Agent (CA) greatly enhances the chances of identifying several diseases that are very difficult to diagnose by other means. The efficacy of a new CA is described by the longitudinal and transverse relaxivity. Nuclear Magnetic Relaxation Dispersion (NMRD) profiles represent the evolution of relaxivities with the magnetic field. Many efforts have been made to develop theoretical models to depict water proton relaxation in the presence of magnetic compounds. Theoretical models used jointly with NMRD profiles have become powerful tools to characterize MNPs as a CA. In this work, a heuristic theoretical model was implemented, verified, and assessed with different magnetic materials. It is demonstrated that the model works well when using iron cores, but fails with other magnetic compounds. A weighting factor associated to Langevin function was also introduced to the model. This extra calibration enables the model to be used with other magnetic compounds to characterize new CAs in MRI. | |
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Internacional
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Si |
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JCR del ISI
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No |
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Título de la revista
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Nanobiomedicine |
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ISSN
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1849-5435 |
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Factor de impacto JCR
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Información de impacto
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Volumen
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DOI
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10.5772/62149 |
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Número de revista
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