Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
A Comparison of Magnetometry and Relaxometry Measures of Magnetic Nanoparticles Deposited in Biological Samples
Year:2015
Research Areas
  • Electronic technology and of the communications
Information
Abstract
The Alternating Gradient Field Magnetometer (AGFM) is an instrument whose high sensitivity (10-8 emu) allows the detection of small amounts of magnetic nanoparticles (MNPs) with high accuracy. Over the last few years, different magnetic techniques have been used for in vitro measurements of magnetic nanostructures inside biological tissues. However, in vivo studies about their distribution within the body are very scarce because their dispersion, after being delivered, reduces their magnetic signal and hinders detection. In this paper we compare the longitudinal relaxation time (T1) and magnetization measurements in mice's biological tissues for the tracking of MNPs after of an injection of iron oxide nanoparticles. Furthermore, we have correlated the AGFM data with Fast Field Cycling NMR Relaxometry (FFCNMR Relaxometry) measurements with histological analysis. The results have demonstrated that these techniques are useful for detecting minute amounts of MNPs in excised organs after comparable to other more conventional techniques for the measurement of MNPs biodistribution and clearance. Details about the preparation of the ex vivo samples, measurement protocol and statistical data processing are given.
International
Si
JCR
Si
Title
Journal of Nano Research
ISBN
1662-5250
Impact factor JCR
0,515
Impact info
Volume
31
Journal number
From page
129
To page
137
Month
SIN MES
Ranking
Participants
  • Autor: Jose Javier Serrano Olmedo (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnologías de Apoyo a la Vida
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)