Observatorio de I+D+i UPM

Memorias de investigación
Artículos en revistas:
A Comparison of Magnetometry and Relaxometry Measures of Magnetic Nanoparticles Deposited in Biological Samples
Año:2015
Áreas de investigación
  • Tecnología electrónica y de las comunicaciones
Datos
Descripción
The Alternating Gradient Field Magnetometer (AGFM) is an instrument whose high sensitivity (10-8 emu) allows the detection of small amounts of magnetic nanoparticles (MNPs) with high accuracy. Over the last few years, different magnetic techniques have been used for in vitro measurements of magnetic nanostructures inside biological tissues. However, in vivo studies about their distribution within the body are very scarce because their dispersion, after being delivered, reduces their magnetic signal and hinders detection. In this paper we compare the longitudinal relaxation time (T1) and magnetization measurements in mice's biological tissues for the tracking of MNPs after of an injection of iron oxide nanoparticles. Furthermore, we have correlated the AGFM data with Fast Field Cycling NMR Relaxometry (FFCNMR Relaxometry) measurements with histological analysis. The results have demonstrated that these techniques are useful for detecting minute amounts of MNPs in excised organs after comparable to other more conventional techniques for the measurement of MNPs biodistribution and clearance. Details about the preparation of the ex vivo samples, measurement protocol and statistical data processing are given.
Internacional
Si
JCR del ISI
Si
Título de la revista
Journal of Nano Research
ISSN
1662-5250
Factor de impacto JCR
0,515
Información de impacto
Volumen
31
DOI
Número de revista
Desde la página
129
Hasta la página
137
Mes
SIN MES
Ranking
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Participantes
  • Autor: Jose Javier Serrano Olmedo (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Grupo de Investigación: Tecnologías de Apoyo a la Vida
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2018 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)