Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Wheat allergy in celiac children
Year:2015
Research Areas
  • Natural sciences and health sciences,
  • Molecular, cellular and genetic biology,
  • Biological sciences,
  • Plants and animal biology and ecology,
  • Biological sciences,
  • Environmental science
Information
Abstract
Gluten is the main structural protein complex of wheat with equivalent toxic proteins found in other cereals (rye, barley, and oats) which are responsible for different immunologic responses with different clinical expressions of disease. The spectrum of gluten-related disorders has been classified according to pathogenic, clinical, and epidemiological differences in three main forms: (i) wheat allergy (WA), an IgE-mediated disease; (ii) autoimmune disease, including celiac disease (CD), dermatitis herpetiformis, and gluten ataxia; and (iii) possibly immune-mediated, gluten sensitivity [1]. WA is an immunologic Th2 response with typical manifestations which can vary from dermatological, respiratory, and/or intestinal to anaphylactic reactions. In contrast, CD is an autoimmune disorder, a gliadin-specific T-cell response which is enhanced by the action of intestinal tissue transglutaminase (tTG), with a wide clinical spectrum including symptomatic cases with either intestinal (e.g., chronic diarrhea, weight loss) or extraintestinal features (e.g., anemia, osteoporosis, neurologic disturbances) and silent forms that are occasionally discovered as a result of serological screening [1]. We studied wheat allergy in two children with early diagnosis of CD, who developed immediate allergic symptoms after eating small amounts of wheat flour.
International
Si
JCR
Si
Title
Pediatric Allergy And Immunology
ISBN
0905-6157
Impact factor JCR
3,859
Impact info
Volume
27
Journal number
From page
92
To page
106
Month
SIN MES
Ranking
Participants
  • Autor: MF Martín-Muñoz (Allergy Department, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain. fmartinmz@gmail.com.)
  • Autor: D Rivero (Allergy Department, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.)
  • Autor: Araceli Diaz Perales (UPM)
  • Autor: I Polanco (Pediatric Department, Hospital La Paz Instituto de Investigación (idiPaz), Madrid, Spain.)
  • Autor: S Quirce (Allergy Department, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)