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Descripción
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| Cancer is a leading cause of mortality worldwide. There were an estimated 8.2 million deaths and around 14 million new cases in 2012. It is anticipated that in the next 20 years, the number of people affected will increase by approximately 70% [1,2]. Currently, the magnetic hyperthermia mediated superparamagnetic magnetite particles (SMPs) is a promising alternative antitumor therapy due to its ability to destroy cancer cells by increasing temperature in the localized area. SMPs emitted as heat absorbing energy of an alternating magnetic field causing an increase in temperature and consequently tumor destruction. The Center for Biomedical Technology (CTB) in collaboration with the Center for Industrial Electronics (CIE) attached to the Technical University of Madrid (UPM), they have designed and built a device that uses the heat generated by the SMPs for warm-ups in small volumes samples and whose physical basis of alternating magnetic fields due to eddy current losses and Brown and Néel relaxation. The equipment consists of a coil, an electronic switch that generates square, triangular and trapezoidal waves and variables, a DC source to provide power to the circuit. For these experiments were used SMPs an average diameter of 14 nm ± 3 nm uncoated, which were synthesized at the Center for Molecular Recognition and Technological Development (IDM) of the Technical University of Valencia (UPV). This work represents the latest enhancement magnetic hyperthermia team which is a modification of the control software using Labview. On the other hand, an increase in temperature was achieved using the same concentration of SMP by modifying the methodology that included variations in electrical parameters such as waveform, pending changes, frequency, and current [3,4]. 46 experiments among which include the variation in the concentration of SMPs, the sweep frequency, varying the duty cycle of the square and trapezoidal signal and increasing the amplitude of the current is performed. They established the optimal thermal parameters of the device and a significant improvement was observed in relation to the temperature rise using square waves to contrast them with the sinusoidal signals, with the main contribution since in traditional magnetic hyperthermia forms of sinusoidal signals are used. To date it has achieved a temperature increase of 15 ° C from ambient temperature. Future work is expected to perform experiments with biocompatible coatings and SMPs with different concentrations, toxicity studies, in-vitro testing, and finally in vivo testing. | |
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Internacional
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Si |
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Nombre congreso
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Latest Advances on Nanomaterials for Biomedical Applications (Nanobioapp) 2015 |
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Tipo de participación
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970 |
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Lugar del congreso
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Barcelona (España) |
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Revisores
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Si |
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ISBN o ISSN
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0000-0000 |
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DOI
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Fecha inicio congreso
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21/09/2015 |
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Fecha fin congreso
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23/09/2015 |
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Desde la página
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0 |
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Hasta la página
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0 |
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Título de las actas
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http://congresses.icmab.es/nanobioapp2015/speakers/final-programme |