Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Development of a versatile procedure for the biofunctionalization ofTi-6Al-4V implants
Year:2016
Research Areas
  • Biomedicine,
  • Molecular, cellular and genetic biology
Information
Abstract
tTitanium (Ti) and titanium alloys are among the most-commonly used metallic materials for implantationin the human body for the purpose of replacing hard tissue. Although Ti and its alloys are widely usedfor such an aim, in implants of a long duration they exhibit some shortcomings due to the loosening ofthe very implant. This phenomenon is highly dependent on the interaction between the organic tissuesand the surface of the implant. In this study, the authors introduce a surface treatment technique forfunctionalization of the surface of Ti-6Al-4V alloy with amino groups that could help to control thisinteraction. The functionalized layer was deposited by activated vapor silanization (AVS), which has beenproven as a reliable and robust technique with other materials. The resulting biofunctional layers werecharacterized by atomic force microscopy and fluorescence microscopy, with the optimal conditions forthe deposition of a homogeneous film with a high density of amino groups being determined. Additionally,the non-toxic nature and stability of the biofunctional layer were confirmed by cell culturing. The resultsshow the formation of a homogeneous biofunctional amine layer on Ti-6Al-4V alloy that may be used asa platform for the subsequent covalent immobilization of proteins or other biomolecules.
International
Si
JCR
Si
Title
Applied Surface Science
ISBN
0169-4332
Impact factor JCR
2,538
Impact info
Datos JCR del año 2013
Volume
10.1016
Journal number
387
From page
652
To page
660
Month
JUNIO
Ranking
Participants
  • Autor: Parsa Rezvanian (UPM)
  • Autor: Maria Arroyo Hernández (UPM)
  • Autor: Milagros Ramos Gomez (UPM)
  • Autor: Rafael Daza Garcia (UPM)
  • Autor: Manuel Elices Calafat (UPM)
  • Autor: Gustavo Victor Guinea Tortuero (UPM)
  • Autor: Jose Perez Rigueiro (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Tecnología Fotónica y Bioingeniería
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)