Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration
Year:2015
Research Areas
  • Natural sciences and health sciences
Information
Abstract
We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two strains of rats. Strain-specific differences were observed prior to cocaine self-administration: LEW rats had significantly larger dendritic diameters but lower spine density than the F344 strain. After cocaine self-administration, proximal dendritic volume, dendritic surface area and spine density were increased in LEW rats, where a higher percentage of larger spines were also observed. In addition, we found a strong positive correlation between dendritic volume and spine morphology, and a moderate correlation between dendritic volume and spine density in cocaine self-administered LEW rats, an effect that was not evident in any other condition. By contrast, after cocaine self-administration, F334 rats showed decreased spine head volumes. Our findings suggest that genetic differences could play a key role in the structural plasticity induced by cocaine in CA1 pyramidal neurons. These cocaine-induced alterations could be related to differences in the memory processing of drug reward cues that could potentially explain differential individual vulnerability to cocaine addiction.
International
Si
JCR
Si
Title
Addict Biol
ISBN
1355-6215
Impact factor JCR
5,359
Impact info
Volume
0.1111/adb.12294
Journal number
From page
1
To page
15
Month
SEPTIEMBRE
Ranking
Participants
  • Autor: Santiago M. Coria (epartamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia,)
  • Autor: Abraham Selvas (epartamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia,)
  • Autor: Asta Kastanauskaite . (UPM)
  • Autor: Isabel Fernaud Espinosa (UPM)
  • Autor: Javier De Felipe Oroquieta (UPM)
  • Autor: Emilio Ambrosio (Departamento de Psicobiología, Facultad de Psicología, Universidad Nacional de Educación a Distancia,)
  • Autor: Miguel Miguens Vazquez (UPM)
Research Group, Departaments and Institutes related
  • Creador: Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Arquitectura y Tecnología de Sistemas Informáticos
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)