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Descripción
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| Expressed in somatosensory neurons of the dorsal root and trigeminal ganglion, the transient receptor potential melastatin 8 (TRPM8) channel is a Ca2+-permeable cation channel activated by cold, voltage, PIP2 and menthol. Although TRPM8 channel gating has been characterized at the single channel and macroscopic current levels, there is currently no consensus regarding the extent to which temperature and voltage sensors couple to the conduction gate. In the present study we extended the range of voltages at which the TRPM8-induced ionic currents were measured and made careful measurements of the maximum open probability the channel can attain at different temperatures by means of fluctuation analysis. | |
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Internacional
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Si |
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JCR del ISI
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Si |
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Título de la revista
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Biophysical Journal |
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ISSN
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0006-3495 |
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Factor de impacto JCR
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3,668 |
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Información de impacto
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Cuartil: Q1 (mitad superior) Datos JCR del año 2012 For 2013, the journal BIOPHYSICAL JOURNAL has an Impact Factor of 3.832. |
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Volumen
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108 |
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DOI
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10.1016/j.bpj.2014.11.233 |
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Número de revista
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2 suppl.1 |
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Desde la página
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37 |
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Hasta la página
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38 |
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Mes
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ENERO |
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Ranking
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Category Name: BIOPHYSICS Total Journals in Category: 74 Journal Rank in Category: 18 Quartile in Category: Q1 |