Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Identification of novel components of the Unfolded Protein Response in Arabidopsis.
Year:2015
Research Areas
  • Molecular, cellular and genetic biology
Information
Abstract
Unfavorable environmental and developmental conditions may cause disturbances in protein folding in the endoplasmic reticulum (ER) that are recognized and counteracted by components of the Unfolded Protein Response (UPR) signaling pathways. The early cellular responses include transcriptional changes to increase the folding and processing capacity of the ER. In this study, we systematically screened a collection of inducible transgenic Arabidopsis plants expressing a library of transcription factors for resistance toward UPR-inducing chemicals. We identified 23 candidate genes that may function as novel regulators of the UPR and of which only three genes (bZIP10, TBF1, and NF-YB3) were previously associated with the UPR. The putative role of identified candidate genes in the UPR signaling is supported by favorable expression patterns in both developmental and stress transcriptional analyses. We demonstrated that WRKY75 is a genuine regulator of the ER-stress cellular responses as its expression was found to be directly responding to ER stress-inducing chemicals. In addition, transgenic Arabidopsis plants expressing WRKY75 showed resistance toward salt stress, connecting abiotic and ER-stress responses.
International
Si
JCR
Si
Title
Frontiers in plant science
ISBN
00000000
Impact factor JCR
4,495
Impact info
Volume
7
doi.org/10.3389/fpls.2016.00650
Journal number
From page
2
To page
12
Month
ENERO
Ranking
Participants
  • Autor: A. Hossain
  • Autor: Dennys Marcela Gomez Paez (UPM)
  • Autor: Joaquin Medina Alcazar (UPM)
  • Autor: Jesus Vicente Carbajosa (UPM)
  • Autor: A Orellana
  • Autor: Jan Zouhar (UPM)
  • Autor: C Henríquez-Valencia
Research Group, Departaments and Institutes related
  • Creador: Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)