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Descripción
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| Our laboratory is interested in understanding the genetic regulation of different aspects of plant reproductive development. Part of this analysis is focused on the characterization of the Arabidopsis locus EARLY BOL TING IN SHORT DAYS (EBS) that encodes a gene expression regulator bearing a PLANT HOMEODOMAIN (PHD) zinc finger and a BROMOADJACENT HOMOLOGY (BAH) domain . EBS is member of a plant specific family of chromatin related proteins. Results previously obtained in our laboratory show that EBS is necessary for the repression of the floral integrator gene FT. Moreover, the PHD present in EBS mediates the specific binding of this protein to di- or trimethylated lysine 4 (K4) in histone H3 (H3K4me2/ 3), and loss-of-function mutations in EBS gene cause an increased accumulation of histone H3 acetylation in regulatory sequences of FT. Furthermore, EBS directly binds regulatory regions of this central regulator gene of flowering, and interacts in vivo with histone deacetylases such as HDA6. Altogether these observations indicate that EBS is necessary to maintain a transcriptionally inactive conformation in the chromatin of its target genes, playing a crucial role in the fine tuning of the time of flowering in Arabidopsis. EBS has additional roles in the control of developmental proce ~ ses in plants, including the expression of floral identity genes and reproductive meristem function . Progress in our understanding of the molecular mechanisms underlying EBS function in the modulatíon of gene expression and reproductive development will be presented . | |
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Internacional
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Si |
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ISSN o ISBN
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00000000 |
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Entidad relacionada
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WORKSHOP ON MECHANISMS CONTROLLI NG FLOWER DEVELOPM ENT |
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Nacionalidad Entidad
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Sin nacionalidad |
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Lugar del congreso
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GIRONA, ESPAÑA |