Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention
Year:2016
Research Areas
  • Physiology,
  • Physiology of exercise,
  • Molecular, cellular and genetic biology
Information
Abstract
The ?-2 and ?-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18?50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (p = 0.019, 2.5 kg) and BMI (p = 0.019, 0.88 kg/m2) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (p = 0.036), in addition to an interaction with exercise for fat mass (p = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (p = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles.
International
Si
JCR
Si
Title
Applied Physiology, Nutrition, And Metabolism
ISBN
1715-5312
Impact factor JCR
1,91
Impact info
Volume
41
10.1139/apnm-2015-0425
Journal number
3
From page
307
To page
314
Month
SIN MES
Ranking
26/82
Participants
  • Autor: Barbara Szendrei Szabo (UPM)
  • Autor: Pedro Jose Benito Peinado (UPM)
  • Autor: Fco. Javier Calderon Montero (UPM)
  • Autor: Rocio Cupeiro Coto (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Investigación del Laboratorio de Fisiología del Esfuerzo.
  • Departamento: Salud y Rendimiento Humano
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
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