Observatorio de I+D+i UPM

Memorias de investigación
Communications at congresses:
How to turn birch pollen allergen Bet v 1a as hypoallergenic as Bet v 1d? By loading with retinoic acid
Year:2016
Research Areas
  • Natural sciences and health sciences,
  • Molecular mechanism of disease
Information
Abstract
In spite of being structurally highly homologous, the two isoforms Bet v 1a (Bet v 1.0101) and Bet v 1d (Bet v 1.0102) of the major birch pollen allergen have diverse allergenic potency: Bet v 1a is allergenic, but Bet v 1d is regarded a hypoallergen. We hypothesized that the ligand-binding capacity of these lipocalin-like molecules could discriminate the level of allergenicity. We investigated thus whether the active vitamin A metabolite retinoic acid (RA) can bind to Bet v 1a or Bet v 1d, and how this affects their allergenicity in vitro .
International
Si
Congress
EAACI 2016
970
Place
Viena
Reviewers
Si
ISBN/ISSN
1398-9995
Start Date
11/06/2016
End Date
15/06/2016
From page
505
To page
506
Late Breaking Poster Session LB TPS 6. New treatment modalities in Immunotherapy
Participants
  • Autor: Luis Fernandez Pacios (UPM)
  • Autor: k hufnagl
  • Autor: S wagner
  • Autor: M Wallner
  • Autor: M wiederstein
  • Autor: G hofstetter
  • Autor: F roth-walter
  • Autor: E jensen-jarolim
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Biotecnología Vegetal
  • Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Departamento: Sistemas y Recursos Naturales
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