Observatorio de I+D+i UPM

Memorias de investigación
Communications at congresses:
DERIVATION OF A TEST STATISTIC FOR EMPHYSEMA QUANTIFICATION
Year:2016
Research Areas
  • Bioinstrumentation,
  • Medical equipment,
  • Electronic technology and of the communications
Information
Abstract
Density masking is the de-facto quantitative imaging phenotype for emphysema that is widely used by the clinical community. Density masking defines the burden of emphysema by a fixed threshold, usually between -910 HU and -950 HU, that has been experimentally validated with histology. In this work, we formalized emphysema quantification by means of statistical inference. We show that a non-central Gamma is a good approximation for the local distribution of image intensities for normal and emphysema tissue. We then propose a test statistic in terms of the sample mean of a truncated noncentral Gamma random variable. Our results show that this approach is well-suited for the detection of emphysema and superior to standard density masking. The statistical method was tested in a dataset of 1337 samples obtained from 9 different scanner models in subjects with COPD. Results showed an increase of 17% when compared to the density masking approach, and an overall accuracy of 94.09%.
International
Si
Congress
IEEE International Symposium on Biomedical Imaging (ISBI 2016)
960
Place
Praga (republica Checa)
Reviewers
Si
ISBN/ISSN
978-1-4799-2350-2
10.1109/ISBI.2016.7493498
Start Date
13/04/2016
End Date
16/04/2016
From page
1269
To page
1273
Proceedings
Participants
  • Autor: Gonzalo Vegas Sánchez-Ferrero (UPM)
  • Autor: Maria Jesus Ledesma Carbayo (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnología de imágenes biomédicas
  • Centro o Instituto I+D+i: Centro de I+d+i en Procesado de la Información y Telecomunicaciones
  • Departamento: Ingeniería Electrónica
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)