Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Correlate With Electroencephalography
Year:2016
Research Areas
  • Natural sciences and health sciences,
  • Clinical medicine and epidemiology,
  • Biomedicine,
  • Molecular, cellular and genetic biology
Information
Abstract
Recently, cerebrospinal fluid (CSF) biomarkers related to Alzheimer?s disease (AD) have garnered a lot of clinical attention. To explore neurophysiological traits of AD and parameters for its clinical diagnosis, we examined the association between CSF biomarkers and electroencephalography (EEG) parameters in 14 probable AD patients. Using exact low-resolution electromagnetic tomography (eLORETA), artifact-free 40-sesond EEG data were estimated with current source density (CSD) and lagged phase synchronization (LPS) as the EEG parameters. Correlations between CSF biomarkers and the EEG parameters were assessed. Patients with AD showed significant negative correlation between CSF beta-amyloid (A?)-42 concentration and the logarithms of CSD over the right temporal area in the theta band. Total tau concentration was negatively correlated with the LPS between the left frontal eye field and the right auditory area in the alpha-2 band in patients with AD. Our study results suggest that AD biomarkers, in particular CSF A?42 and total tau concentrations are associated with the EEG parameters CSD and LPS, respectively. Our results could yield more insights into the complicated pathology of AD.
International
Si
JCR
Si
Title
Clinical Eeg And Neuroscience
ISBN
1550-0594
Impact factor JCR
1,862
Impact info
Volume
Journal number
From page
1
To page
10
Month
SIN MES
Ranking
Participants
  • Autor: Leonides Canuet Delis (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnologías para Ciencias de la Salud
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Tecnología Fotónica y Bioingeniería
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)