Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Applicability of epithelial models in protein permeability/transport studies and food allergy
Year:2016
Research Areas
  • Molecular, cellular and genetic biology
Information
Abstract
Measurement of protein transport across the intestinal barrier might be a relevant approach in allergenicity risk assessment. Traditionally, studies on protein transport, were performed using stable cell lines cultured as a monolayer. One of the major advantages of these models is their relatively low price and easy handling. However, monolayers lack a physiologically relevant environment (presence of other cell-types and a mucus layer), which may have an effect on transport characteristics and thus correct prediction of protein allergenicity. This paper summarizes the most widely used epithelial models and discusses their benefits and limitations for measuring protein transport and allergic sensitization to food
International
No
JCR
No
Title
Drug Discovery Today. Disease Models
ISBN
1740-6757
Impact factor JCR
Impact info
Volume
10.1016/j.ddmod.2016.08.002
Journal number
From page
1
To page
9
Month
SIN MES
Ranking
Participants
  • Autor: Nuria Cubells Baeza (UPM)
  • Autor: K.C.M Verhoeckx (TNO)
  • Autor: C Larre (INRA)
  • Autor: S Denery-Papini (INRA,)
  • Autor: M. Gavrovic-Jankulovic (University of Belgrade)
  • Autor: Araceli Diaz Perales (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Biotecnología - Biología Vegetal
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)