Descripción
|
|
---|---|
The lipid transfer protein Pru p 3 is one of the most common plant food allergens among adults in Southern Europe with a prevalence that has been increasing particularly in children. LTP allergy is frequently life-long and is also one of the causes of anaphylactic reactions that are potentially life-threatening. However, the origin of its immunological activity is unknown.The nature of the lipid-ligand of Pru p 3 has recently been identified as a derivative of the alkaloid camptothecin linked to a phytosphingosine tail. Taking into account that lipids can induce immune responses, in this work we have evaluated the immunogenic activity of this lipid-ligand using a range of in vitro models (moDC, PBMCs, THP1 and epithelial cells as Caco2), and a mouse model of anaphylaxis to peach. We have determined that the lipid-ligand of Pru p 3 could act as an adjuvant with the ability to modulate the immune system presumably toward a Th2 response characteristic of allergy as it has been demonstrated in a mouse model of anaphylaxis. Moreover, the lipid-ligand of Pru p 3 co-localized to CD1d in epithelial cells (Caco2) and interacted to Cd1d tetramers to activate iNKT of the immune system. | |
Internacional
|
Si |
JCR del ISI
|
Si |
Título de la revista
|
Clinical And Experimental Allergy |
ISSN
|
0954-7894 |
Factor de impacto JCR
|
5,587 |
Información de impacto
|
Datos JCR del año 2015 |
Volumen
|
|
DOI
|
10.1111/cea.12962 |
Número de revista
|
|
Desde la página
|
1 |
Hasta la página
|
10 |
Mes
|
SIN MES |
Ranking
|