Observatorio de I+D+i UPM

Memorias de investigación
Research Project:
BD2Decide: Big Data and models for personalized Head and Neck Cancer Decision support
Year:2016
Research Areas
Information
Abstract

"Cancers of the Head and Neck Region (HNC) are the 6th more deadly cancers worldwide: in Europe ~150.000 new cases are detected and ~70.000 patients die every year. The main reasons for high mortality are the fact that the majority of cases are diagnosed in advanced Stage and the intrinsic heterogeneity of such tumors. At present the only adopted treatment decision method is based on TNM (Tumor-lymph-Nodes-Metastasis) prognostic system, that considers only a few risk factors such as smoking, alcohol abuse and more recently HPV. The TNM system is therefore inadequate to capture the patient-specific biomolecular characteristics of the tumor. HNC treatments can have hard impact on patient’s aesthetics and functionalities and, due to their toxicity, can cause severe morbidity and greatly deteriorate patient’s quality of life. A more precise prognostic prediction than the current TNM system is needed that allows implementing the first-line treatment that maximizes the therapeutic result and minimizes the impacts of therapy.
BD2Decide DSS provides clinicians with the ""means"" and all the necessary information to tailor treatment and care delivery pathway to each and any HNC patient during their usual practice, in contrast to current “one-size-fits-all approach”. BD2Decide realizes and validates an Integrated Decision Support System that links population-specific epidemiology and behavioral data, patient-specific genomic, pathology, clinical and imaging data with big data techniques, multiscale prognostic models. Advanced graphical visualization tools are developed for prognostic data disclosure and patient co-participation to the selected treatment. BD2Decide will improve the clinical decision process, uncover new patient-specific patterns that can improve care, and create a virtuous circle of learning. A multicentric clinical study with more than 1.000 patients will be used to validate the system.

International
Si
Project type
Proyectos y convenios en convocatorias públicas competitivas
Company
Entity Nationality
Sin nacionalidad
Entity size
Granting date
12/11/2015
Participants
  • Participante: Giuseppe Fico (UPM)
  • Participante: Alessio Fioravanti . (UPM)
  • Participante: Alejandro Medrano Gil (UPM)
  • Participante: Laura López Pérez (UPM)
  • Participante: Ana Maria Ugena Martinez (UPM)
  • Director: Maria Teresa Arredondo Waldmeyer (UPM)
Research Group, Departaments and Institutes related
  • Creador: No seleccionado
  • Centro o Instituto I+D+i: Centro de tecnología Biomédica CTB
  • Departamento: Matemática Aplicada a Las Tecnologías de la Información y Las Comunicaciones
  • Departamento: Tecnología Fotónica y Bioingeniería
  • Grupo de Investigación: Tecnologías de Apoyo a la Vida
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)