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Memorias de investigación
Ponencias en congresos:
Hypothesis from Nanopublications created by SADI services
Áreas de investigación
  • Ciencias naturales y ciencias de la salud
We describe how NanoPublications can be automatically generated through executing an analytical workflow, and how the scientific assertions in NanoPublications can be assembled into novel, explicit, machine-readable hypotheses. NanoPublications (NPs) [1] are fine-grained, machine-readable, scientific assertions (e.g. ProteinX represses GeneY) that are explicitly connected to their provenance (i.e. justification and citation information). Their machine-readability makes them excellent candidates for novel hypothesis generation via large-scale data integration [2]. SADI [3] defines a simple set of rules for how online bioinformatics tools should ?behave?. These rules make it easier to pipeline multiple analytical tools into complex bioinformatics analysis workflows. Unfortunately, at this time, these analytical workflows do not retain much information about their execution ? for example, the time/date, resources used, software versions, input/output data, etc. As such, the conclusion of the analysis does not carry its full provenance. We therefore describe an approach for automatically generating NPs from SADI services, such that experiments, and their conclusions, are annotated in great detail. Second, we show how novel scientific hypotheses can be generated by assembling NPs. We previously demonstrated that scientific hypothesis could be written in well-structured machine-readable logics[4]. Since each NP carries one scientific assertion, many NPs can be combined to act as the logical premises for these hypotheses. NP-based hypotheses are novel in two ways: First, they are explicit and transparent, and not subject to vagueness or misinterpretation. Second, they are machine-readable, and in many cases can be automatically evaluated by software through the discovery and execution of SADI analytical workflows.
Nombre congreso
Workshop New Frontiers in Plant Biology
Tipo de participación
Lugar del congreso
Centro de Biotecnología y Genómica de Plantas
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Título de las actas
Hypothesis from Nanopublications created by SADI services
Esta actividad pertenece a memorias de investigación
  • Autor: Adrian Jose Garcia Puertas (UPM)
  • Autor: Mark Denis Wilkinson (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Centro o Instituto I+D+i: Centro de Biotecnología y Genómica de Plantas, CBGP
  • Departamento: Biotecnología - Biología Vegetal
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