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Descripción
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| The establishment of polarity is a critical process in pathogenic fungi. Here, we report the identification of TPC1 (Transcription factor for Polarity Control 1), which regulates invasive polarized growth in the rice blast fungus Magnaporthe oryzae. TPC1 encodes a putative transcription factor of the fungal Zn(II)2Cys6 family, exclusive to filamentous fungi. TPC1-deficient mutants showed severe defects in conidiogenesis, infection-associated autophagy, glycogen metabolism and plant tissue colonisation. By tracking actin-binding proteins, septin-5 and autophagosome components, we show that TPC1 regulates cytoskeletal dynamics and infection-associated autophagy during appressorium-mediated plant penetration. Importantly, we found that Tpc1 regulates NoxD, the p22phox sub-unit of the fungal NADPH oxidase complex. Tpc1 therefore controls the spatial and temporal regulation of cortical F-actin through regulation of the NADPH oxidase complex during appressorium re-polarisation. We conclude that Tpc1 is a core developmental regulator in filamentous fungi, linking the regulated synthesis of reactive oxygen species with polarity control during host invasion. | |
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Internacional
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Si |
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Nombre congreso
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Workshop New Frontiers in Plant Biology |
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Tipo de participación
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970 |
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Lugar del congreso
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Centro de Biotecnología y Genómica de Plantas |
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Revisores
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Si |
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ISBN o ISSN
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0000-0000 |
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DOI
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Fecha inicio congreso
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15/06/2016 |
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Fecha fin congreso
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17/06/2016 |
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Desde la página
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18 |
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Hasta la página
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18 |
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Título de las actas
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The transcriptional regulator Tpc1 is required for NADPH oxidase-dependent polarized growth and virulence in the rice blast fungus |