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Memorias de investigación
Communications at congresses:
Deciphering the molecular mechanism underlying the broad-spectrum disease resistance regulated by ERECTA-YODA immune pathway
Year:2016
Research Areas
  • Natural sciences and health sciences
Information
Abstract
YODA (YDA) is a MAPK kinase kinase (MAP3K) that functions downstream the Receptor Like Kinase (RLK) ERECTA (ER). YDA-ER pathway control Arabidopsis immune responses, but also stomatal patterning and other plant developmental-associated processes. Remarkably, plants expressing a constitutively active form of YDA (CA-YDA) show broad-spectrum disease resistance to different type of pathogens, including fungi, oomycetes, and bacteria. CA-YDA-mediated resistance is independent of defensive pathways regulated by salicylic acid, jasmonic acid or ethylene, and of previously characterised canonical immune pathways activated by Microbe-Associated Molecular Patterns (MAMPs). Comparative transcriptomic analyses of mock and fungal-inoculated wild-type and CA-YDA plants revealed that CA-YDA plants constitutively express a set of defense-associated genes, which encoded uncharacterised RLKs and putative extracellular peptides (ePEPs). We selected Arabidopsis mutants impaired in the expression of these ePEPs and tested their contribution to resistance against the fungal pathogen Plectosphaerella cucumerina BMM, the bacterium Pseudomonas syringae pv. tomato DC3000 and the oomycete Hyaloperonospora arabidopsidis Noco2. Remarkably, we found that some of these peptides contribute to Arabidopsis immunity since ePEPs mutants showed enhanced susceptibility to these pathogens. ER-YDA define a novel immune pathway that orchestrates broad-spectrum resistance by regulating defensive responses that act in parallel to canonical disease resistance pathways. We propose that plants evolutionarily co-opted the ER-YDA pathway to generate a novel immune surveillance system linked to stomata development, since these plant apertures are pathogen entry points.
International
Si
Congress
Plant Peptides & Receptors 2016
970
Place
Bischoffsheim,+France
Reviewers
Si
ISBN/ISSN
0000-0000
Start Date
31/08/2016
End Date
02/09/2016
From page
0
To page
0
Plant Peptides & Receptors 2016
Participants
  • Autor: Sanjay Swami . (UPM)
  • Autor: Lucia Jorda Miro (UPM)
  • Autor: Sara Sopeña Torres (UPM)
  • Autor: Clara Sánchez Rodríguez (UPM)
  • Autor: Viviana Pamela Escudero Welsch (UPM)
  • Autor: Yangnan Go
  • Autor: Antonio Molina Fernandez (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Biotecnología - Biología Vegetal
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