Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
When Transcriptomics and Metabolomics Work Hand in Hand: A Case Study Characterizing Plant CDF Transcription Factors
Year:2018
Research Areas
  • Molecular, cellular and genetic biology
Information
Abstract
Over the last three decades, novel ?omics? platform technologies for the sequencing of DNA and complementary DNA (cDNA) (RNA-Seq), as well as for the analysis of proteins and metabolites by mass spectrometry, have become more and more available and increasingly found their way into general laboratory life. With this, the ability to generate highly multivariate datasets on the biological systems of choice has increased tremendously. However, the processing and, perhaps even more importantly, the integration of ?omics? datasets still remains a bottleneck, although considerable computational and algorithmic advances have been made in recent years. In this mini-review, we use a number of recent ?multi-omics? approaches realized in our laboratories as a common theme to discuss possible pitfalls of applying ?omics? approaches and to highlight some useful tools for data integration and visualization in the form of an exemplified case study. In the selected example, we used a combination of transcriptomics and metabolomics alongside phenotypic analyses to functionally characterize a small number of Cycling Dof Transcription Factors (CDFs). It has to be remarked that, even though this approach is broadly used, the given workflow is only one of plenty possible ways to characterize target proteins.
International
Si
JCR
Si
Title
High-Throughput
ISBN
2571-5135
Impact factor JCR
Impact info
Volume
7
10.3390/ht7010007
Journal number
1
From page
7
To page
7
Month
FEBRERO
Ranking
Participants
  • Autor: Marta Marina Perez Alonso (UPM)
  • Autor: Víctor Carrasco Loba (UPM)
  • Autor: Joaquin Medina Alcazar (UPM)
  • Autor: Jesus Vicente Carbajosa (UPM)
  • Autor: Stephan Pollmann (UPM)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Redes Reguladoras del Desarrollo y Respuesta a Estrés en Plantas
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)