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Descripción
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| Although the fate of parasites is often determined by its ability for adapting to its host(s), little is known on the mechanisms and determinants of host adaptation. This is especially so for sterilizing parasites, which may have devastating effects on host populations as they prevent host reproduction. Theory predicts that sterilizing parasites would evolve towards absolute host sterilization and lower virulence to optimize resource exploitation. However, this hypothesis has seldom been analysed experimentally. We investigated host adaptation processes of the sterilizing plant virus Turnip mosaic virus (TuMV) to its natural host Arabidopsis thaliana by serial passage experiments. After passaging, we quantified virus accumulation, effect on plant growth and development, and virulence of the ancestral and passaged viral genotypes in A. thaliana. Results indicated that passaging increased the proportion of infected plants showing absolute sterility, reduced TuMV virulence, and increased virus multiplication, therefore resulting in host adaptation. Genomic comparison of the ancestral and passaged TuMV genotypes mapped candidate genetic determinants of host adaptation in viral proteins (P1, P3, and 6K2) with host-dependent functions. Thus, our results support theoretical predictions, and contribute to better understand the phenotypic and genetic changes leading to host adaptation. | |
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Internacional
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Si |
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Nombre congreso
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9th Workshop in Virus Evolution |
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Tipo de participación
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960 |
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Lugar del congreso
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Toftrees Cnference Center; State College, PA, USA |
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Revisores
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Si |
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ISBN o ISSN
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000-00-0000-000-0 |
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DOI
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Fecha inicio congreso
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09/03/2017 |
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Fecha fin congreso
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12/03/2017 |
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Desde la página
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7 |
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Hasta la página
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7 |
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Título de las actas
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Abstracts |