Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
The challenge of mapping the human connectome based on diffusion tractography
Year:2017
Research Areas
  • Medical equipment,
  • Electronic technology and of the communications,
  • Electronic equipment
Information
Abstract
Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations
International
Si
JCR
Si
Title
Nature Communications
ISBN
2041-1723
Impact factor JCR
12,124
Impact info
Volume
8
10.1038/s41467-017-01285-x
Journal number
From page
1
To page
13
Month
NOVIEMBRE
Ranking
Lugar en el Área ?Multidisciplinary Sciences?: 3/64 (D1)
Participants
  • Autor: Klaus Maier-Hein
  • Autor: Peter Neher
  • Autor: Oscar Esteban Sanz-Dranguet (UPM)
  • Autor: Maxime Descoteaux
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Tecnología de imágenes biomédicas
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)