Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Characterization of a new toxin from the entomopathogenic fungus Metarhizium anisopliae: the ribotoxin anisoplin
Year:2017
Research Areas
  • Entomology
Information
Abstract
Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extraordinary efficiency against ribosomes and suggested as potential insecticides. Here we describe this ribotoxin characteristic activity in M. anisopliae cultures. Anisoplin has been obtained as a recombinant protein and further characterized. It is structurally similar to hirsutellin A, the ribotoxin from the entomopathogen Hirsutella thompsonii. Moreover, anisoplin shows the ribonucleolytic activity typical of ribotoxins and cytotoxicity against insect cells. How Metarhizium uses this toxin and possible applications are of interest.
International
Si
JCR
Si
Title
Biological Chemistry
ISBN
1431-6730
Impact factor JCR
3,273
Impact info
Volume
398
Journal number
From page
135
To page
142
Month
SIN MES
Ranking
Participants
  • Autor: Miriam Olombrada (U. Complutense de Madrid)
  • Autor: Maria Pilar Medina Velez (UPM)
  • Autor: Maria Flor Budia Marigil (UPM)
  • Autor: José G. Gavilanes (U. Complutense de Madrid)
  • Autor: Álvaro Martínez del Pozo (U. Complutense de Madrid)
  • Autor: Lucía García-Ortega (U. Complutense de Madrid)
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Manejo Integrado de Plagas
  • Departamento: Producción Agraria
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)