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Descripción
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| Circular RNA (circRNA) is mainly generated by the splice donor of a downstream exon joining to an upstream splice acceptor, a phenomenon known as backsplicing. It has been reported that circRNA can function as microRNA (miRNA) sponges, transcriptional regulators, or potential biomarkers. The availability of massive non-polyadenylated transcriptomes data has facilitated the genome-wide identification of thousands of circRNAs. Several circRNA detection tools or pipelines have recently been developed, and it is essential to provide useful guidelines on these pipelines for users, including a comprehensive and unbiased comparison. Here, we provide an improved and easy-to-use circRNA read simulator that can produce mimicking backsplicing reads supporting circRNAs deposited in CircBase. | |
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Internacional
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Si |
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JCR del ISI
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Si |
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Título de la revista
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Plos Computational Biology |
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ISSN
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1553-734X |
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Factor de impacto JCR
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4,542 |
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Información de impacto
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Volumen
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DOI
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Número de revista
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Desde la página
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687 |
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Hasta la página
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695 |
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Mes
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SIN MES |
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Ranking
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