Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
A comprehensive overview and evaluation of circular RNA detection tools
Year:2017
Research Areas
  • Artificial intelligence (neuronal nets, expert systems, etc),
  • Computational biology
Information
Abstract
Circular RNA (circRNA) is mainly generated by the splice donor of a downstream exon joining to an upstream splice acceptor, a phenomenon known as backsplicing. It has been reported that circRNA can function as microRNA (miRNA) sponges, transcriptional regulators, or potential biomarkers. The availability of massive non-polyadenylated transcriptomes data has facilitated the genome-wide identification of thousands of circRNAs. Several circRNA detection tools or pipelines have recently been developed, and it is essential to provide useful guidelines on these pipelines for users, including a comprehensive and unbiased comparison. Here, we provide an improved and easy-to-use circRNA read simulator that can produce mimicking backsplicing reads supporting circRNAs deposited in CircBase.
International
Si
JCR
Si
Title
Plos Computational Biology
ISBN
1553-734X
Impact factor JCR
4,542
Impact info
Volume
Journal number
From page
687
To page
695
Month
SIN MES
Ranking
Participants
  • Autor: Xiangxiang Zeng (UPM)
  • Autor: Wei Lin
  • Autor: Maozu Guo
  • Autor: Quan Zou
Research Group, Departaments and Institutes related
  • Creador: Grupo de Investigación: Grupo de Inteligencia Artificial (LIA)
  • Departamento: Inteligencia Artificial
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)