Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Functional Connectivity Disruption in Subjective Cognitive Decline and Mild Cognitive Impairment: a Common Pattern of Alterations
Year:2017
Research Areas
  • Cognitive neuroscience
Information
Abstract
Functional connectivity (FC) alterations represent a key feature in Alzheimer's Disease (AD) and provide a useful tool to characterize and predict the course of the disease. Those alterations have been also described in Mild Cognitive Impairment (MCI), a prodromal stage of AD. There is a growing interest in detecting AD pathology in the brain in the very early stages of the disorder. Subjective Cognitive Decline (SCD) could represent a preclinical asymptomatic stage of AD but very little is known about this population. In the present work we assessed whether FC disruptions are already present in this stage, and if they share any spatial distribution properties with MCI alterations (a condition known to be highly related to AD). To this end, we measured electromagnetic spontaneous activity with MEG in 39 healthy control elders, 41 elders with SCD and 51 MCI patients. The results showed FC alterations in both SCD and MCI compared to the healthy control group. Interestingly, both groups exhibited a very similar spatial pattern of altered links: a hyper-synchronized anterior network and a posterior network characterized by a decrease in FC. This decrease was more pronounced in the MCI group. These results highlight that elders with SCD present FC alterations. More importantly, those disruptions affected AD typically related areas and showed great overlap with the alterations exhibited by MCI patients. These results support the consideration of SCD as a preclinical stage of AD and may indicate that FC alterations appear very early in the course of the disease.
International
Si
JCR
Si
Title
Frontiers in Aging Neuroscience
ISBN
1663-4365
Impact factor JCR
4,504
Impact info
Datos JCR del año 2016
Volume
9
10.3389/fnagi.2017.00109
Journal number
From page
109
To page
109
Month
SIN MES
Ranking
Participants
  • Autor: David López Sanz (UPM)
  • Autor: Ricardo Bruña Fernandez (UPM)
  • Autor: Mª Pilar Garcés López (UPM)
  • Autor: María del Carmen Martín-Buro
  • Autor: Stefan Walter
  • Autor: María Luisa Delgado
  • Autor: Mercedes Montenegro
  • Autor: Ramón López Higes
  • Autor: Alberto Marcos
  • Autor: Fernando Maestu Unturbe (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Tecnología Fotónica y Bioingeniería
S2i 2019 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)