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Memorias de investigación
Artículos en revistas:
Functional Connectivity Disruption in Subjective Cognitive Decline and Mild Cognitive Impairment: a Common Pattern of Alterations
Año:2017
Áreas de investigación
  • Neurociencia cognitiva
Datos
Descripción
Functional connectivity (FC) alterations represent a key feature in Alzheimer's Disease (AD) and provide a useful tool to characterize and predict the course of the disease. Those alterations have been also described in Mild Cognitive Impairment (MCI), a prodromal stage of AD. There is a growing interest in detecting AD pathology in the brain in the very early stages of the disorder. Subjective Cognitive Decline (SCD) could represent a preclinical asymptomatic stage of AD but very little is known about this population. In the present work we assessed whether FC disruptions are already present in this stage, and if they share any spatial distribution properties with MCI alterations (a condition known to be highly related to AD). To this end, we measured electromagnetic spontaneous activity with MEG in 39 healthy control elders, 41 elders with SCD and 51 MCI patients. The results showed FC alterations in both SCD and MCI compared to the healthy control group. Interestingly, both groups exhibited a very similar spatial pattern of altered links: a hyper-synchronized anterior network and a posterior network characterized by a decrease in FC. This decrease was more pronounced in the MCI group. These results highlight that elders with SCD present FC alterations. More importantly, those disruptions affected AD typically related areas and showed great overlap with the alterations exhibited by MCI patients. These results support the consideration of SCD as a preclinical stage of AD and may indicate that FC alterations appear very early in the course of the disease.
Internacional
Si
JCR del ISI
Si
Título de la revista
Frontiers in Aging Neuroscience
ISSN
1663-4365
Factor de impacto JCR
4,504
Información de impacto
Datos JCR del año 2016
Volumen
9
DOI
10.3389/fnagi.2017.00109
Número de revista
Desde la página
109
Hasta la página
109
Mes
SIN MES
Ranking
Esta actividad pertenece a memorias de investigación
Participantes
  • Autor: David López Sanz (UPM)
  • Autor: Ricardo Bruña Fernandez (UPM)
  • Autor: Mª Pilar Garcés López (UPM)
  • Autor: María del Carmen Martín-Buro
  • Autor: Stefan Walter
  • Autor: María Luisa Delgado
  • Autor: Mercedes Montenegro
  • Autor: Ramón López Higes
  • Autor: Alberto Marcos
  • Autor: Fernando Maestu Unturbe (UPM)
Grupos de investigación, Departamentos, Centros e Institutos de I+D+i relacionados
  • Creador: Departamento: Tecnología Fotónica y Bioingeniería
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