Observatorio de I+D+i UPM

Memorias de investigación
Research Publications in journals:
Meta-path methods for prioritizing candidate disease miRNAs
Year:2017
Research Areas
  • Computational biology
Information
Abstract
MicroRNAs (miRNAs) play critical roles in regulating gene expression at post-transcriptional levels. Predicting potential miRNAdisease association is beneficial not only to explore the pathogenesis of diseases, but also to understand biological processes. In this work, we propose two methods that can effectively predict potential miRNAdisease associations using our reconstructed miRNA and disease similarity networks, which are based on the latest experimental data. We reconstruct a miRNA functional similarity network using the following biological information: the miRNA family information, miRNA cluster information, experimentally valid miRNA target association and disease miRNA information. We also reconstruct a disease similarity network using disease functional information and disease semantic information. We present Katz with specific weights and Katz with machine learning, on the comprehensive heterogeneous network. These methods, which achieve corresponding AUC values of 0.897 and 0.919, exhibit performance superior to the existing methods. Comprehensive data networks and reasonable considerations guarantee the high performance of our methods. Contrary to several methods, which cannot work in such situations, the proposed methods also predict associations for diseases without any known related miRNAs.
International
Si
JCR
Si
Title
Ieee/Acm Transactions on Computational Biology And Bioinformatics
ISBN
1545-5963
Impact factor JCR
Impact info
Volume
10.1109/TCBB.2017.2776280
Journal number
From page
1
To page
1
Month
SIN MES
Ranking
Participants
  • Autor: Xuan Zhang
  • Autor: Quan Zou
  • Autor: Alfonso Vicente Rodriguez-Paton Aradas (UPM)
  • Autor: Xiangxiang Zeng (UPM)
Research Group, Departaments and Institutes related
  • Creador: Departamento: Inteligencia Artificial
S2i 2020 Observatorio de investigación @ UPM con la colaboración del Consejo Social UPM
Cofinanciación del MINECO en el marco del Programa INNCIDE 2011 (OTR-2011-0236)
Cofinanciación del MINECO en el marco del Programa INNPACTO (IPT-020000-2010-22)